Seroatlas · Human Serome Atlas

TP53I13

Tumor protein p53-inducible protein 13

Also known as: DSCP1, P5I13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NBR0
Gene: TP53I13
Ensembl: ENSG00000167543
Chromosome: 17
Canonical length: 393 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Involved in negative regulation of cell cycle; response to UV; and response to xenobiotic stimulus. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

393 residues, UniProt reviewed canonical sequence.

>Q8NBR0|TP53I13
     1  MAPPPPSPQL LLLAALARLL GPSEVMAGPA EEAGAHCPES LWPLPPQVSP RVTYTRVSPG
    61  QAEDVTFLYH PCAHPWLKLQ LALLAYACMA NPSLTPDFSL TQDRPLVLTA WGLALEMAWV
   121  EPAWAAHWLM RRRRRKQRKK KAWIYCESLS GPAPSEPTPG RGRLCRRGCV QALALAFALR
   181  SWRPPGTEVT SQGPRQPSSS GAKRRRLRAA LGPQPTRSAL RFPSASPGSL KAKQSMAGIP
   241  GRESNAPSVP TVSLLPGAPG GNASSRTEAQ VPNGQGSPGG CVCSSQASPA PRAAAPPRAA
   301  RGPTPRTEEA AWAAMALTFL LVLLTLATLC TRLHRNFRRG ESIYWGPTAD SQDTVAAVLK
   361  RRLLQPSRRV KRSRRRPLLP PTPDSGPEGE SSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TP53I13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 114 nTPM

Expression across tissuesHPA

Tissue

liver: 114 nTPM
pituitary gland: 91 nTPM
spleen: 78 nTPM
small intestine: 77 nTPM
adipose tissue: 69 nTPM
kidney: 67 nTPM

Single-cell type

early primary spermatocytes: 34 nCPM
late primary spermatocytes: 32 nCPM
pdcs: 24 nCPM
megakaryocytes: 19 nCPM
differentiating spermatogonia: 16 nCPM
prostatic club cells: 15 nCPM

Immune cell

plasmacytoid DC: 111 nTPM
basophil: 53 nTPM
NK-cell: 29 nTPM
gdT-cell: 27 nTPM
MAIT T-cell: 27 nTPM
myeloid DC: 26 nTPM

Brain region

choroid plexus: 42 nTPM
medulla oblongata: 37 nTPM
white matter: 34 nTPM
thalamus: 32 nTPM
midbrain: 32 nTPM
basal ganglia: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.07
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TP53I13 as an antibody target. Whether an autoantibody or antibody against TP53I13 could matter depends on whether native TP53I13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TP53I13 is annotated at the cell surface, where native TP53I13 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TP53I13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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