Seroatlas · Human Serome Atlas

TP53I11

Tumor protein p53-inducible protein 11

Also known as: P5I11_HUMAN, PIG11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14683
Gene: TP53I11
Ensembl: ENSG00000175274
Chromosome: 11
Canonical length: 189 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Endoplasmic reticulum,Golgi apparatus,Acrosome,Principal piece

OverviewNCBI Gene

Predicted to be involved in negative regulation of cell population proliferation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>O14683|TP53I11
     1  MAAKQPPPLM KKHSQTDLVS RLKTRKILGV GGEDDDGEVH RSKISQVLGN EIKFTIREPL
    61  GLRVWQFVSA VLFSGIAIMA LAFPDQLYDA VFDGAQVTSK TPIRLYGGAL LSISLIMWNA
   121  LYTAEKVIIR WTLLTEACYF GVQFLVVTAT LAETGLMSLG ILLLLVSRLL FVVISIYYYY
   181  QVGRRPKKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TP53I11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 72 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 72 nTPM
heart muscle: 68 nTPM
cerebellum: 63 nTPM
breast: 60 nTPM
spleen: 58 nTPM
blood vessel: 50 nTPM

Single-cell type

late spermatids: 958 nCPM
cardiomyocytes: 201 nCPM
early spermatids: 152 nCPM
neutrophils: 90 nCPM
salivary ionocytes: 81 nCPM
cytotrophoblasts: 75 nCPM

Immune cell

neutrophil: 41 nTPM
plasmacytoid DC: 25 nTPM
non-classical monocyte: 21 nTPM
naive B-cell: 8.4 nTPM
memory B-cell: 8.1 nTPM
NK-cell: 8.1 nTPM

Brain region

amygdala: 90 nTPM
cerebellum: 88 nTPM
midbrain: 69 nTPM
hypothalamus: 61 nTPM
cerebral cortex: 61 nTPM
pons: 56 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TP53I11.

Disease | ImmuneIEDB

Conditions an epitope on TP53I11 was assayed in.

chronic lymphocytic leukemia T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0.31
gnomAD missense Z: 1.82
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of cell population proliferation

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Tumor protein p53-inducible protein 11
Tumour protein p53-inducible protein 11

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TP53I11 as an antibody target. Whether an autoantibody or antibody against TP53I11 could matter depends on whether native TP53I11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TP53I11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TP53I11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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