Seroatlas · Human Serome Atlas

TP53AIP1

p53-regulated apoptosis-inducing protein 1

Also known as: p53AIP1, TPIP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCN2
Gene: TP53AIP1
Ensembl: ENSG00000120471
Chromosome: 11
Canonical length: 124 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependent apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

124 residues, UniProt reviewed canonical sequence.

>Q9HCN2|TP53AIP1
     1  MGSSSEASFR SAQASCSGAR RQGLGRGDQN LSVMPPNGRA QTHTPGWVSD PLVLGAQVHG
    61  GCRGIEALSV SSGSWSSATV WILTGLGLGL SRPFLPGATV LRDRPLGSAF ELSYDQKKAP
   121  LRLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TP53AIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.75
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

thymus: 28 nTPM
esophagus: 25 nTPM
skin: 19 nTPM
cervix: 15 nTPM
vagina: 14 nTPM
salivary gland: 3.8 nTPM

Single-cell type

esophageal basal cells: 158 nCPM
epididymal efferent duct ciliated cells: 114 nCPM
breast myoepithelial cells: 77 nCPM
basal keratinocytes: 56 nCPM
endometrial ciliated cells: 39 nCPM
epididymal basal cells: 30 nCPM

Immune cell

basophil: 0.2 nTPM
neutrophil: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 3.9 nTPM
cerebral cortex: 3.7 nTPM
hypothalamus: 3.7 nTPM
medulla oblongata: 3.6 nTPM
midbrain: 3.6 nTPM
pons: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.95
gnomAD pLI: 0
gnomAD missense Z: 0.04
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

apoptotic process

Cellular components

Protein domainsUniProt · Pfam · InterPro

p53-regulated apoptosis-inducing protein 1
p53-regulated apoptosis-inducing protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TP53AIP1 as an antibody target. Whether an autoantibody or antibody against TP53AIP1 could matter depends on whether native TP53AIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TP53AIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TP53AIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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