Seroatlas · Human Serome Atlas

TOX2

TOX high mobility group box family member 2

Also known as: C20orf100, dJ1108D11.2, GCX-1, TOX2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96NM4
Gene: TOX2
Ensembl: ENSG00000124191
Chromosome: 20
Canonical length: 488 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

488 residues, UniProt reviewed canonical sequence.

>Q96NM4|TOX2
     1  MQQTRTEAVA GAFSRCLGFC GMRLGLLLLA RHWCIAGVFP QKFDGDSAYV GMSDGNPELL
    61  STSQTYNGQS ENNEDYEIPP ITPPNLPEPS LLHLGDHEAS YHSLCHGLTP NGLLPAYSYQ
   121  AMDLPAIMVS NMLAQDSHLL SGQLPTIQEM VHSEVAAYDS GRPGPLLGRP AMLASHMSAL
   181  SQSQLISQMG IRSSIAHSSP SPPGSKSATP SPSSSTQEEE SEVHFKISGE KRPSADPGKK
   241  AKNPKKKKKK DPNEPQKPVS AYALFFRDTQ AAIKGQNPSA TFGDVSKIVA SMWDSLGEEQ
   301  KQSSPDQGET KSTQANPPAK MLPPKQPMYA MPGLASFLTP SDLQAFRSGA SPASLARTLG
   361  SKSLLPGLSA SPPPPPSFPL SPTLHQQLSL PPHAQGALLS PPVSMSPAPQ PPVLPTPMAL
   421  QVQLAMSPSP PGPQDFPHIS EFPSSSGSCS PGPSNPTSSG DWDSSYPSGE CGISTCSLLP
   481  RDKSLYLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

thymus: 47 nTPM
hypothalamus: 30 nTPM
lung: 30 nTPM
pituitary gland: 21 nTPM
midbrain: 19 nTPM
cerebral cortex: 18 nTPM

Single-cell type

corticotrophs: 266 nCPM
innate lymphoid cells: 252 nCPM
sertoli cells: 176 nCPM
thyrotrophs: 131 nCPM
lactotrophs: 84 nCPM
oocytes: 83 nCPM

Immune cell

eosinophil: 6.6 nTPM
plasmacytoid DC: 2.6 nTPM
T-reg: 1.2 nTPM
NK-cell: 1.1 nTPM
neutrophil: 0.7 nTPM
memory CD4 T-cell: 0.3 nTPM

Brain region

hypothalamus: 76 nTPM
thalamus: 46 nTPM
midbrain: 40 nTPM
cerebral cortex: 38 nTPM
pons: 34 nTPM
medulla oblongata: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0.03
gnomAD missense Z: 0.59
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TOX2 as an antibody target. Whether an autoantibody or antibody against TOX2 could matter depends on whether native TOX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TOX2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TOX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...