Seroatlas · Human Serome Atlas

TOPAZ1

Protein TOPAZ1

Also known as: C3orf77, FLJ36157, TOPZ1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9V7
Gene: TOPAZ1
Ensembl: ENSG00000173769
Chromosome: 3
Canonical length: 1692 aa
Protein class: Predicted intracellular proteins
Subcellular location: Acrosome,Mid piece

OverviewNCBI Gene

Predicted to be involved in spermatocyte division. Predicted to act upstream of or within apoptotic process; ectopic germ cell programmed cell death; and lncRNA transcription. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1692 residues, UniProt reviewed canonical sequence.

>Q8N9V7|TOPAZ1
     1  MRRPPPLGPT TASGPEGNVR NLQKRQAPGP GAAGGCGPEA GGCRENKQKR RMVARATPGR
    61  GEVESDKSVA ASGAGKAARR QVEGRRGPVS PSDSSDPRGL EAAKEAELPL QTERHTKEKR
   121  KVTEASSDDP QPGLDLVRKE SLTSSESFQT VECLQSLGKE SIIEGIKRRI RNKKLKSLEN
   181  PPLKITENEA TQNIKVEFQD ELYKNTPKYS CNILSPEVEN NSVLKLRDCN CFPHSKGCND
   241  ENNLPYKPDG GCMHVAENFS KKENLRSLAE KSDTNSIPQL LQTEENVMGV NKLLPEESDL
   301  YQSKTNGLLS CLQHEKNKYS IEESSVGRKP RKRMKLSEKA DETVTEMNFS NEYNKSELML
   361  QENQMIADGK EAETKSPLNV LRKVSHNTVS LMDHLLSVPE TVEKETSSEH HVNAVFQKTI
   421  EPLLKEETEN ASEPLGYESM ASKEDFKSMK SFIGKSPNEY HIERRSSRED LRSASEELKL
   481  SCQRTIPMTG KRTWPYYSCA RISAWCWKKA SLPESSYFLR GSQESCRQVD VPKHQTNQTH
   541  LTDSKLLLQS SLTETNTESS SKEKLDSNSN CLSSVSAVEP TLMVIKEPII KDDKKIKSEE
   601  LSRRGSEVIS NTTEDTQLTS ETQSLTGNKK KARGNLTKLN LTATSKDGQE ANNSAGKTIH
   661  RKACIAQQTF IVPDLVKILN TGRLTNFKIP LLKNKSEKRK EVNAKSSERE AYSPLELLDN
   721  LSGADVRQNR SKENVSMMML GPQTLSIRNS VTPVQASSDS FYNKKSYSIS PSFTKQGNNS
   781  KPSNHVSEPG NIVSNKEVAS LTVENNAFSC DPGYVEKSPS FCCNEQETFR PVSSEVRGRK
   841  ITKNFSEVGF PDILKAYEDD VLLIDVIQDD PDLFGVSNEG ELSFTSEVPK ISQEPNVAGE
   901  HQSTDSKYME TPVKKEPSDD LRELPVLDCG WIKPDICASN SAESEIKRDP KDVNTSLGEV
   961  ANETSENETL GDFSEQIKGS DLDEKHRFTD KVITKEEKEN IYEVCKSKDS RNADFMVGEC
  1021  QFAVPVPKPL CLLVPPLNLS GRQEDTILNT WMNDFRFLGK HSVLKLQNPE TCEIFKREKN
  1081  VGVFQKSLGL MIPYKYCKFH FNTLRGCERP LCKFAHVPEQ GDEKVCMDVF KKYININELC
  1141  LLQRAVNIFM EYYRKFPPGV YFDLQVLNDL LNSLLKHCLL KEVFQIVNLS IMVKMLPSLK
  1201  ILLNIFEYVA TMKLRNAVPA LIDIFCKLVE AGMVLDPEHF NYIVKLLYQV QASKQEITAV
  1261  LEMKSRLQMR RFKKNWKCDL DSALNKLEHC KEKGDWTKLG KLYINVKMGC EKFADFQTFC
  1321  ACIAETLTKN YEDERPDIPF CEFAETVSKD PQNSKVDKGV LGRIGISAMY FYHKLLQWSK
  1381  GRKVLEKLYE LKIHFTSLKG LIGPEKLASR CQIVNVAAEI FLKSGSLDGA IWVMRESEWI
  1441  INTPLWPCDR LDVLNRHNLL CTIAHEILAK SLYRQTFEVL QNLPGFQNSQ ETVEVSQYSL
  1501  LFNKLLGSCI ESSSLGMSSS VAEFMISKSI PIDFSFLRRL ITSLGRSRLW LKARAHYKSA
  1561  LSLGCYPPLE GNLYRKLLLI PSYLSEIEML LAIEIFMVSN ASSIQSPGTS TQILQIVLKR
  1621  CEDNQSRSND DYQAAVERLI MAARISDPKL FVKHMTVNVN KEQVYSLEHC SALKWLKENM
  1681  KWAGKVWLFS NH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOPAZ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 3.3 nTPM

Expression across tissuesHPA

Tissue

testis: 3.3 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early primary spermatocytes: 217 nCPM
undifferentiated spermatogonia: 82 nCPM
differentiating spermatogonia: 76 nCPM
late primary spermatocytes: 17 nCPM
oocytes: 9.2 nCPM
late spermatids: 3.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
hippocampal formation: 0.3 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM
choroid plexus: 0.2 nTPM
midbrain: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.98
gnomAD missense Z: 1.9
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

Protein TOPAZ1 domain
Protein TOPAZ1
Putative aspartate racemase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TOPAZ1 as an antibody target. Whether an autoantibody or antibody against TOPAZ1 could matter depends on whether native TOPAZ1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TOPAZ1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TOPAZ1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...