Seroatlas · Human Serome Atlas

TOMT

Transmembrane O-methyltransferase

Also known as: CFAP111, COMT2, DFNB63, LRRC51, LRTOMT, LRTOMT1, LRTOMT2, TOMT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WZ04
Gene
TOMT
Ensembl
ENSG00000284922
Chromosome
11
Canonical length
291 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Microtubules

OverviewNCBI Gene

This locus represents naturally occurring readthrough transcription between the neighboring LRRC51 (leucine-rich repeat containing 51) and TOMT (transmembrane O-methyltransferase) genes on chromosome 11. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. Multiple reports implicate mutations in this gene in nonsyndromic deafness.[provided by RefSeq, Feb 2021]

Canonical amino-acid sequenceUniProt

291 residues, UniProt reviewed canonical sequence.

>Q8WZ04|TOMT
     1  MGTPWRKRKG IAGPGLPDLS CALVLQPRAQ VGTMSPAIAL AFLPLVVTLL VRYRHYFRLL
    61  VRTVLLRSLR DCLSGLRIEE RAFSYVLTHA LPGDPGHILT TLDHWSSRCE YLSHMGPVKG
   121  QILMRLVEEK APACVLELGT YCGYSTLLIA RALPPGGRLL TVERDPRTAA VAEKLIRLAG
   181  FDEHMVELIV GSSEDVIPCL RTQYQLSRAD LVLLAHRPRC YLRDLQLLEA HALLPAGATV
   241  LADHVLFPGA PRFLQYAKSC GRYRCRLHHT GLPDFPAIKD GIAQLTYAGP G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOMT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
8.5 nTPM

Expression across tissuesHPA

Tissue

  • testis: 8.5 nTPM
  • fallopian tube: 4.8 nTPM
  • cerebellum: 0.7 nTPM
  • endometrium: 0.7 nTPM
  • liver: 0.4 nTPM
  • prostate: 0.4 nTPM

Single-cell type

  • cardiomyocytes: 52 nCPM
  • late spermatids: 26 nCPM
  • epicardial cells: 18 nCPM
  • adipocytes: 14 nCPM
  • mesothelial cells: 13 nCPM
  • platelets: 7.1 nCPM

Immune cell

  • memory CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 1.3 nTPM
  • hypothalamus: 1.3 nTPM
  • white matter: 1.3 nTPM
  • basal ganglia: 1.1 nTPM
  • cerebral cortex: 1.1 nTPM
  • medulla oblongata: 1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TOMT.

Disease | AllUniProt

Conditions TOMT is implicated in, by any mechanism.

  • Deafness, autosomal recessive, 63 (DFNB63) MIM:611451

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.2
gnomAD pLI
0
DepMap mean gene effect
0.14
DepMap dependency class
none

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TOMT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TOMT as an antibody target. Whether an autoantibody or antibody against TOMT could matter depends on whether native TOMT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TOMT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TOMT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TOMT. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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