Seroatlas · Human Serome Atlas

TOMM40L

Mitochondrial import receptor subunit TOM40B

Also known as: FLJ12770, TM40L_HUMAN, TOMM40B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969M1
Gene: TOMM40L
Ensembl: ENSG00000158882
Chromosome: 1
Canonical length: 308 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrion. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

308 residues, UniProt reviewed canonical sequence.

>Q969M1|TOMM40L
     1  MGNTLGLAPM GTLPRRSPRR EEPLPNPGSF DELHRLCKDV FPAQMEGVKL VVNKVLSSHF
    61  QVAHTIHMSA LGLPGYHLHA AYAGDWQLSP TEVFPTVVGD MDSSGSLNAQ VLLLLAERLR
   121  AKAVFQTQQA KFLTWQFDGE YRGDDYTATL TLGNPDLIGE SVIMVAHFLQ SLTHRLVLGG
   181  ELVYHRRPGE EGAILTLAGK YSAVHWVATL NVGSGGAHAS YYHRANEQVQ VGVEFEANTR
   241  LQDTTFSFGY HLTLPQANMV FRGLVDSNWC VGAVLEKKMP PLPVTLALGA FLNHWRNRFH
   301  CGFSITVG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOMM40L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

tongue: 48 nTPM
heart muscle: 23 nTPM
skeletal muscle: 22 nTPM
liver: 20 nTPM
cerebral cortex: 19 nTPM
bone marrow: 14 nTPM

Single-cell type

megakaryocytes: 31 nCPM
neutrophils: 27 nCPM
monocytes: 17 nCPM
hofbauer cells: 13 nCPM
esophageal basal cells: 11 nCPM
enterocytes: 10 nCPM

Immune cell

plasmacytoid DC: 3.4 nTPM
myeloid DC: 3 nTPM
basophil: 2.5 nTPM
intermediate monocyte: 1.9 nTPM
NK-cell: 1.9 nTPM
naive CD8 T-cell: 1.7 nTPM

Brain region

cerebral cortex: 24 nTPM
thalamus: 23 nTPM
basal ganglia: 20 nTPM
amygdala: 20 nTPM
white matter: 20 nTPM
medulla oblongata: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.67
gnomAD missense Z: 1.43
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TOMM40L as an antibody target. Whether an autoantibody or antibody against TOMM40L could matter depends on whether native TOMM40L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TOMM40L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TOMM40L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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