TOMM20L
TOMM20-like protein 1
Also known as: TO20L_HUMAN, UNQ9438
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UXN7
- Gene
- TOMM20L
- Ensembl
- ENSG00000196860
- Chromosome
- 14
- Canonical length
- 152 aa
- Protein class
- Predicted membrane proteins
OverviewNCBI Gene
Predicted to enable mitochondrion targeting sequence binding activity. Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix and tRNA import into mitochondrion. Predicted to be located in mitochondrial outer membrane. Predicted to be part of mitochondrial outer membrane translocase complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
152 residues, UniProt reviewed canonical sequence.
>Q6UXN7|TOMM20L
1 MPSVRSLLRL LAAAAACGAF AFLGYCIYLN RKRRGDPAFK RRLRDKRRAE PQKAEEQGTQ
61 LWDPTKNKKL QELFLQEVRM GELWLSRGEH RMGIQHLGNA LLVCEQPREL LKVFKHTLPP
121 KVFEMLLHKI PLICQQFEAD MNEQDCLEDD PDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TOMM20L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.44
- Highest tissue expression
- 10 nTPM
Expression across tissuesHPA
Tissue
- testis: 10 nTPM
- epididymis: 0.9 nTPM
- parathyroid gland: 0.5 nTPM
- thyroid gland: 0.5 nTPM
- kidney: 0.4 nTPM
- prostate: 0.4 nTPM
Single-cell type
- early spermatids: 133 nCPM
- late primary spermatocytes: 130 nCPM
- late spermatids: 11 nCPM
- thymocytes: 6.8 nCPM
- early primary spermatocytes: 6.6 nCPM
- proximal tubule cells: 3 nCPM
Immune cell
- naive CD8 T-cell: 0.2 nTPM
- memory B-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- cerebellum: 1 nTPM
- white matter: 0.9 nTPM
- amygdala: 0.8 nTPM
- basal ganglia: 0.7 nTPM
- pons: 0.7 nTPM
- cerebral cortex: 0.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.58
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.79
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- intracellular protein transport
- protein import into mitochondrial matrix
- protein targeting
- tRNA import into mitochondrion
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TOMM20L as an antibody target. Whether an autoantibody or antibody against TOMM20L could matter depends on whether native TOMM20L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TOMM20L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TOMM20L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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