Seroatlas · Human Serome Atlas

TOGARAM2

TOG array regulator of axonemal microtubules protein 2

Also known as: Crescerin-2, FAM179A, FLJ43249, LOC165186, TGRM2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZUX3
Gene: TOGARAM2
Ensembl: ENSG00000189350
Chromosome: 2
Canonical length: 1019 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be located in microtubule cytoskeleton. Predicted to be active in cilium and cytoplasmic microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1019 residues, UniProt reviewed canonical sequence.

>Q6ZUX3|TOGARAM2
     1  MGTRDDVPEA KVLVPVAVYC GSIPRTSAGP RVLPPGSINS SLPHGEGSLQ PEPRALLNNE
    61  EPSQLLRGLG QLGGLKLDTP SKGWQARNGH PRNLRALSLG DQPLVLLPSP ESEANSVARD
   121  TIQIKDKLKK RRLSEGLAAS SRASLDPGGG PQGVPLHSTI PRATSQRLLR VPRPMPLIQS
   181  IPTTPEASGV KEKGLDLPGS IPGPHELRPG AQEAQISWQY LHCNDEKMQK SLGAIVIPPI
   241  PKARTVAATP SRVPGSLPSP LPPGQGVLTG LRAPRTRLAR GSGPREKTPA SLEPKPLASP
   301  IRDRPAAAKK PALPFSQSAP TLTAFSFDCA REACPPLKEE DQKEIGTKIQ VTISKSAREK
   361  MQLKQMKEME LLRRLEEPRT GQELTSQCLG SQRAFMKEGL LPLRGSGTLS VPTRLSGPCR
   421  NDVSIILRKW ASRASLPSIP ISRQEPRFAR HASANSLPAV LTLGSPEWEE EEEMDLRACK
   481  ELRPFSNPEL GLRDALQCLN SSDWQMKEKG LVSIQRLAAC HSEVLTGKLH DVCLVVTGEV
   541  TNLRSKVSHL AISTLGDLFQ ALKKNMDQEA EEIARCLLQK MADTNEFIQR AAGQSLRAMV
   601  ENVTLARSLV VLTSAGVYHR NPLIRKYAAE HLSAVLEQIG AEKLLSGTRD STDMLVHNLV
   661  RLAQDSNQDT RFYGRKMVNI LMANTKFDAF LKQSLPSYDL QKVMAAIKQQ GIEDNDELPS
   721  AKGRKVLRSL VVCENGLPIK EGLSCNGPRL VGLRSTLQGR GEMVEQLREL TRLLEAKDFR
   781  SRMEGVGQLL ELCKAKTELV TAHLVQVFDA FTPRLQDSNK KVNQWALESF AKMIPLLRES
   841  LHPMLLSIII TVADNLNSKN SGIYAAAVAV LDAMVESLDN LCLLPALAGR VRFLSGRAVL
   901  DVTDRLAVLV ASVYPRKPQA VERHVLPILW HFLNTATRNG TLPGPSGNIR GVVCRLSRSL
   961  QEHMGSRLLD FAASQPKHVL KTLQELLDSE SLGGSRKATD RGVAPDSKTT GSSYPFQLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOGARAM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 19 nTPM
choroid plexus: 7.3 nTPM
skeletal muscle: 3.9 nTPM
basal ganglia: 3.5 nTPM
tongue: 2.8 nTPM
lung: 2.7 nTPM

Single-cell type

ependymal cells: 699 nCPM
bergmann glia: 433 nCPM
respiratory ciliated cells: 402 nCPM
choroid plexus epithelial cells: 224 nCPM
fallopian tube ciliated cells: 212 nCPM
endometrial ciliated cells: 197 nCPM

Immune cell

gdT-cell: 1.6 nTPM
memory CD8 T-cell: 1.1 nTPM
MAIT T-cell: 0.7 nTPM
NK-cell: 0.6 nTPM
T-reg: 0.6 nTPM
naive CD8 T-cell: 0.5 nTPM

Brain region

midbrain: 81 nTPM
choroid plexus: 58 nTPM
medulla oblongata: 48 nTPM
pons: 34 nTPM
spinal cord: 32 nTPM
basal ganglia: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TOGARAM2 as an antibody target. Whether an autoantibody or antibody against TOGARAM2 could matter depends on whether native TOGARAM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TOGARAM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TOGARAM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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