Seroatlas · Human Serome Atlas

TNS4

Tensin-4

Also known as: CTEN, TENS4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZW8
Gene: TNS4
Ensembl: ENSG00000131746
Chromosome: 17
Canonical length: 715 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable actin binding activity. Involved in protein localization. Located in cytosol and focal adhesion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

715 residues, UniProt reviewed canonical sequence.

>Q8IZW8|TNS4
     1  MSQVMSSPLL AGGHAVSLAP CDEPRRTLHP APSPSLPPQC SYYTTEGWGA QALMAPVPCM
    61  GPPGRLQQAP QVEAKATCFL PSPGEKALGT PEDLDSYIDF SLESLNQMIL ELDPTFQLLP
   121  PGTGGSQAEL AQSTMSMRKK EESEALDIKY IEVTSARSRC HDGPQHCSSP SVTPPFGSLR
   181  SGGLLLSRDV PRETRSSSES LIFSGNQGRG HQRPLPPSEG LSPRPPNSPS ISIPCMGSKA
   241  SSPHGLGSPL VASPRLEKRL GGLAPQRGSR ISVLSASPVS DVSYMFGSSQ SLLHSSNSSH
   301  QSSSRSLESP ANSSSSLHSL GSVSLCTRPS DFQAPRNPTL TMGQPRTPHS PPLAKEHASS
   361  CPPSITNSMV DIPIVLINGC PEPGSSPPQR TPGHQNSVQP GAASPSNPCP ATRSNSQTLS
   421  DAPFTTCPEG PARDMQPTMK FVMDTSKYWF KPNITREQAI ELLRKEEPGA FVIRDSSSYR
   481  GSFGLALKVQ EVPASAQSRP GEDSNDLIRH FLIESSAKGV HLKGADEEPY FGSLSAFVCQ
   541  HSIMALALPC KLTIPQRELG GADGASDSTD SPASCQKKSA GCHTLYLSSV SVETLTGALA
   601  VQKAISTTFE RDILPTPTVV HFKVTEQGIT LTDVQRKVFF RRHYPLTTLR FCGMDPEQRK
   661  WQKYCKPSWI FGFVAKSQTE PQENVCHLFA EYDMVQPASQ VIGLVTALLQ DAERM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNS4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 194 nTPM

Expression across tissuesHPA

Tissue

skin: 194 nTPM
vagina: 70 nTPM
salivary gland: 57 nTPM
esophagus: 43 nTPM
cervix: 42 nTPM
prostate: 33 nTPM

Single-cell type

basal keratinocytes: 407 nCPM
salivary basal cells: 402 nCPM
ocular epithelial cells: 328 nCPM
basal prostatic cells: 290 nCPM
salivary myoepithelial cells: 289 nCPM
epicardial cells: 271 nCPM

Immune cell

MAIT T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 0.6 nTPM
choroid plexus: 0.3 nTPM
cerebral cortex: 0.2 nTPM
medulla oblongata: 0.2 nTPM
basal ganglia: 0.1 nTPM
hippocampal formation: 0.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TNS4.

Disease | ImmuneIEDB

Conditions an epitope on TNS4 was assayed in.

colonic benign neoplasm T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: 0.68
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intracellular protein localization

Molecular functions

actin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TNS4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

EGFR

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNS4 as an antibody target. Whether an autoantibody or antibody against TNS4 could matter depends on whether native TNS4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNS4 is annotated at the cell surface, where native TNS4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TNS4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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