Seroatlas · Human Serome Atlas

TNMD

Tenomodulin

Also known as: BRICD4, ChM1L, myodulin, TEM, tendin, TNMD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H2S6
Gene: TNMD
Ensembl: ENSG00000000005
Chromosome: X
Canonical length: 317 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>Q9H2S6|TNMD
     1  MAKNPPENCE DCHILNAEAF KSKKICKSLK ICGLVFGILA LTLIVLFWGS KHFWPEVPKK
    61  AYDMEHTFYS NGEKKKIYME IDPVTRTEIF RSGNGTDETL EVHDFKNGYT GIYFVGLQKC
   121  FIKTQIKVIP EFSEPEEEID ENEEITTTFF EQSVIWVPAE KPIENRDFLK NSKILEICDN
   181  VTMYWINPTL ISVSELQDFE EEGEDLHFPA NEKKGIEQNE QWVVPQVKVE KTRHARQASE
   241  EELPINDYTE NGIEFDPMLD ERGYCCIYCR RGNRYCRRVC EPLLGYYPYP YCYQGGRVIC
   301  RVIMPCNWWV ARMLGRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNMD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

seminal vesicle: 25 nTPM
adipose tissue: 22 nTPM
breast: 14 nTPM
tongue: 5.4 nTPM
ovary: 5.3 nTPM
skeletal muscle: 3.5 nTPM

Single-cell type

leydig cells: 11 nCPM
ovarian stromal cells: 11 nCPM
adipocytes: 10 nCPM
hepatic stellate cells: 6.5 nCPM
vascular endothelial cells: 5.1 nCPM
retinal ganglion cells: 3.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 2.3 nTPM
midbrain: 1.3 nTPM
hypothalamus: 1.2 nTPM
medulla oblongata: 1.2 nTPM
thalamus: 0.7 nTPM
pons: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0
gnomAD missense Z: 0.86
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNMD as an antibody target. Whether an autoantibody or antibody against TNMD could matter depends on whether native TNMD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNMD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TNMD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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