Seroatlas · Human Serome Atlas

TNFSF18

Tumor necrosis factor ligand superfamily member 18

Also known as: AITRL, hGITRL, TL6, TNF18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UNG2
Gene: TNFSF18
Ensembl: ENSG00000120337
Chromosome: 1
Canonical length: 177 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

177 residues, UniProt reviewed canonical sequence.

>Q9UNG2|TNFSF18
     1  MCLSHLENMP LSHSRTQGAQ RSSWKLWLFC SIVMLLFLCS FSWLIFIFLQ LETAKEPCMA
    61  KFGPLPSKWQ MASSEPPCVN KVSDWKLEIL QNGLYLIYGQ VAPNANYNDV APFEVRLYKN
   121  KDMIQTLTNK SKIQNVGGTY ELHVGDTIDL IFNSEHQVLK NNTYWGIILL ANPQFIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFSF18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 1.4 nTPM

Expression across tissuesHPA

Tissue

gallbladder: 1.4 nTPM
pancreas: 1.4 nTPM
cerebral cortex: 1.3 nTPM
esophagus: 0.8 nTPM
liver: 0.6 nTPM
small intestine: 0.6 nTPM

Single-cell type

hofbauer cells: 32 nCPM
epididymal basal cells: 22 nCPM
esophageal apical cells: 17 nCPM
esophageal suprabasal cells: 11 nCPM
macrophages: 7.6 nCPM
cdc: 7.4 nCPM

Immune cell

non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 2.3 nTPM
cerebellum: 1.6 nTPM
hippocampal formation: 1.6 nTPM
medulla oblongata: 1.5 nTPM
pons: 1.5 nTPM
white matter: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: -0.56
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tumour necrosis factor domain
Tumour necrosis factor-like domain superfamily
Tumor necrosis factor ligand superfamily member 18

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNFSF18 as an antibody target. Whether an autoantibody or antibody against TNFSF18 could matter depends on whether native TNFSF18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNFSF18 is annotated at the cell surface, where native TNFSF18 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TNFSF18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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