Seroatlas · Human Serome Atlas

TNFSF13

Tumor necrosis factor ligand superfamily member 13

Also known as: APRIL, CD256, TNF13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75888
Gene
TNFSF13
Ensembl
ENSG00000161955
Chromosome
17
Canonical length
250 aa
Protein class
Cancer-related genes, CD markers, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood
Quaternary structure
Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

250 residues, UniProt reviewed canonical sequence.

>O75888|TNFSF13
     1  MPASSPFLLA PKGPPGNMGG PVREPALSVA LWLSWGAALG AVACAMALLT QQTELQSLRR
    61  EVSRLQGTGG PSQNGEGYPW QSLPEQSSDA LEAWENGERS RKRRAVLTQK QKKQHSVLHL
   121  VPINATSKDD SDVTEVMWQP ALRRGRGLQA QGYGVRIQDA GVYLLYSQVL FQDVTFTMGQ
   181  VVSREGQGRQ ETLFRCIRSM PSHPDRAYNS CYSAGVFHLH QGDILSVIIP RARAKLNLSP
   241  HGTFLGFVKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFSF13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
170 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 170 nTPM
  • salivary gland: 139 nTPM
  • lung: 89 nTPM
  • duodenum: 70 nTPM
  • kidney: 62 nTPM
  • gallbladder: 51 nTPM

Single-cell type

  • astrocytes: 28 nCPM
  • microglia: 12 nCPM
  • bergmann glia: 7.9 nCPM
  • choroid plexus epithelial cells: 7 nCPM
  • ependymal cells: 5.8 nCPM
  • monocytes: 3.5 nCPM

Immune cell

  • classical monocyte: 384 nTPM
  • intermediate monocyte: 364 nTPM
  • myeloid DC: 249 nTPM
  • non-classical monocyte: 236 nTPM
  • total PBMC: 222 nTPM
  • eosinophil: 139 nTPM

Brain region

  • choroid plexus: 98 nTPM
  • thalamus: 47 nTPM
  • medulla oblongata: 47 nTPM
  • basal ganglia: 43 nTPM
  • midbrain: 43 nTPM
  • pons: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.82
gnomAD missense Z
0.53
DepMap mean gene effect
-0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNFSF13 as an antibody target. Whether an autoantibody or antibody against TNFSF13 could matter depends on whether native TNFSF13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNFSF13 is annotated as secreted, so native TNFSF13 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TNFSF13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TNFSF13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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