Seroatlas · Human Serome Atlas

TNFRSF17

Tumor necrosis factor receptor superfamily member 17

Also known as: BCM, BCMA, CD269, TNFRSF13A, TNR17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q02223
Gene
TNFRSF17
Ensembl
ENSG00000048462
Chromosome
16
Canonical length
184 aa
Protein class
Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus,Mitotic spindle

OverviewNCBI Gene

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

184 residues, UniProt reviewed canonical sequence.

>Q02223|TNFRSF17
     1  MLQMAGQCSQ NEYFDSLLHA CIPCQLRCSS NTPPLTCQRY CNASVTNSVK GTNAILWTCL
    61  GLSLIISLAV FVLMFLLRKI NSEPLKDEFK NTGSGLLGMA NIDLEKSRTG DEIILPRGLE
   121  YTVEECTCED CIKSKPKVDS DHCFPLPAME EGATILVTTK TNDYCKSLPA ALSATEIEKS
   181  ISAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFRSF17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 45 nTPM
  • lymph node: 30 nTPM
  • duodenum: 27 nTPM
  • colon: 27 nTPM
  • stomach: 23 nTPM
  • spleen: 21 nTPM

Single-cell type

  • plasma cells: 567 nCPM
  • foveolar cells: 28 nCPM
  • gastric chief cells: 20 nCPM
  • pdcs: 15 nCPM
  • b-cells: 15 nCPM
  • late primary spermatocytes: 12 nCPM

Immune cell

  • memory B-cell: 125 nTPM
  • naive B-cell: 109 nTPM
  • plasmacytoid DC: 104 nTPM
  • total PBMC: 13 nTPM
  • neutrophil: 1.7 nTPM
  • basophil: 1.3 nTPM

Brain region

  • white matter: 3.8 nTPM
  • cerebellum: 3.7 nTPM
  • basal ganglia: 3.6 nTPM
  • medulla oblongata: 3.6 nTPM
  • hippocampal formation: 3.3 nTPM
  • thalamus: 3.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TNFRSF17.

Disease | ImmuneIEDB

Conditions an epitope on TNFRSF17 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.88
gnomAD pLI
0
gnomAD missense Z
-1.24
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNFRSF17 as an antibody target. Whether an autoantibody or antibody against TNFRSF17 could matter depends on whether native TNFRSF17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNFRSF17 is annotated at the cell surface, where native TNFRSF17 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response.

Canonical record: https://seroatlas.com/gene/TNFRSF17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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