TNFRSF13C

Protein identityUniProt · HPA

UniProt accession

Q96RJ3

Gene

TNFRSF13C

Ensembl

ENSG00000159958

Chromosome

22

Canonical length

184 aa

Protein class

CD markers, Disease related genes, Human disease related genes, Predicted membrane proteins

OverviewNCBI Gene

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

184 residues, UniProt reviewed canonical sequence.

>Q96RJ3|TNFRSF13C
     1  MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ
    61  ESVGAGAGEA ALPLPGLLFG APALLGLALV LALVLVGLVS WRRRQRRLRG ASSAEAPDGD
   121  KDAPEPLDKV IILSPGISDA TAPAWPPPGE DPGTTPPGHS VPVPATELGS TELVTTKTAG
   181  PEQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFRSF13C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.67

Highest tissue expression

56 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TNFRSF13C.

Disease | AllUniProt

Conditions TNFRSF13C is implicated in, by any mechanism.

• Immunodeficiency, common variable, 4 (CVID4) MIM:613494

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 210 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Immunodeficiency, common variable, 4

ReferencesPubMed · IEDB

Publications for TNFRSF13C from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.27

gnomAD pLI

0.27

gnomAD missense Z

0.64

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adaptive immune response
• B cell costimulation
• positive regulation of B cell proliferation
• positive regulation of T cell proliferation
• T cell costimulation
• tumor necrosis factor-mediated signaling pathway

Molecular functions

• signaling receptor activity

Cellular components

• external side of plasma membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Tumor necrosis factor receptor 13C/17
• Tumour necrosis factor receptor 13C, TALL-1 binding domain
• Tumour necrosis factor receptor 13C
• BAFF-R, TALL-1 binding

KeywordsUniProt

• Adaptive immunity
• Disulfide bond
• Immunity
• Membrane
• Receptor
• Signal-anchor
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of TNFRSF13C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TRAF1