Seroatlas · Human Serome Atlas

TNFRSF12A

Tumor necrosis factor receptor superfamily member 12A

Also known as: CD266, FN14, TNR12_HUMAN, TweakR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NP84
Gene: TNFRSF12A
Ensembl: ENSG00000006327
Chromosome: 16
Canonical length: 129 aa
Protein class: Cancer-related genes, CD markers, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Involved in positive regulation of extrinsic apoptotic signaling pathway and regulation of wound healing. Predicted to be located in cell surface and ruffle. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

129 residues, UniProt reviewed canonical sequence.

>Q9NP84|TNFRSF12A
     1  MARGSLRRLL RLLVLGLWLA LLRSVAGEQA PGTAPCSRGS SWSADLDKCM DCASCRARPH
    61  SDFCLGCAAA PPAPFRLLWP ILGGALSLTF VLGLLSGFLV WRRCRRREKF TTPIEETGGE
   121  GCPAVALIQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFRSF12A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 147 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 147 nTPM
pancreas: 110 nTPM
heart muscle: 109 nTPM
kidney: 96 nTPM
choroid plexus: 82 nTPM
lung: 76 nTPM

Single-cell type

epididymal basal cells: 901 nCPM
fallopian secretory cells: 707 nCPM
pancreatic duct cells: 588 nCPM
alveolar cells type 1: 535 nCPM
epididymal efferent duct ciliated cells: 450 nCPM
basal keratinocytes: 437 nCPM

Immune cell

eosinophil: 140 nTPM
neutrophil: 103 nTPM
myeloid DC: 15 nTPM
basophil: 12 nTPM
classical monocyte: 12 nTPM
NK-cell: 8 nTPM

Brain region

thalamus: 14 nTPM
cerebral cortex: 13 nTPM
choroid plexus: 11 nTPM
hypothalamus: 11 nTPM
midbrain: 9.3 nTPM
medulla oblongata: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0.02
gnomAD missense Z: -0.14
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tumour necrosis factor receptor 12
Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TNFRSF12A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRAF2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNFRSF12A as an antibody target. Whether an autoantibody or antibody against TNFRSF12A could matter depends on whether native TNFRSF12A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNFRSF12A is annotated at the cell surface, where native TNFRSF12A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TNFRSF12A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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