TNFAIP8L3
Tumor necrosis factor alpha-induced protein 8-like protein 3
Also known as: FLJ41287, TP8L3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5GJ75
- Gene
- TNFAIP8L3
- Ensembl
- ENSG00000183578
- Chromosome
- 15
- Canonical length
- 292 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Predicted to enable phosphatidylinositol binding activity and phosphatidylinositol transfer activity. Predicted to be involved in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process; phospholipid transport; and positive regulation of ERK1 and ERK2 cascade. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
292 residues, UniProt reviewed canonical sequence.
>Q5GJ75|TNFAIP8L3
1 MGKPRQNPST LVSTLCEAEP KGKLWVNGYA GTQGTRDATL QTRLIPLSFH LQRGKGLAAP
61 LSALSAPRLP ERPADGRVAV DAQPAARSMD SDSGEQSEGE PVTAAGPDVF SSKSLALQAQ
121 KKILSKIASK TVANMLIDDT SSEIFDELYK VTKEHTHNKK EAHKIMKDLI KVAIKIGILY
181 RNNQFSQEEL VIVEKFRKKL NQTAMTIVSF YEVEYTFDRN VLSNLLHECK DLVHELVQRH
241 LTPRTHGRIN HVFNHFADVE FLSTLYSLDG DCRPNLKRIC EGINKLLDEK VLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TNFAIP8L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 79 nTPM
Expression across tissuesHPA
Tissue
- smooth muscle: 79 nTPM
- endometrium: 78 nTPM
- fallopian tube: 54 nTPM
- blood vessel: 40 nTPM
- skin: 21 nTPM
- esophagus: 19 nTPM
Single-cell type
- early primary spermatocytes: 169 nCPM
- smooth muscle cells: 102 nCPM
- esophageal apical cells: 90 nCPM
- lymphatic endothelial cells: 63 nCPM
- fallopian tube ciliated cells: 33 nCPM
- thymic myoid cells: 33 nCPM
Immune cell
- basophil: 0.8 nTPM
- neutrophil: 0.4 nTPM
- NK-cell: 0.3 nTPM
- classical monocyte: 0.2 nTPM
- eosinophil: 0.1 nTPM
- intermediate monocyte: 0.1 nTPM
Brain region
- hippocampal formation: 29 nTPM
- amygdala: 16 nTPM
- cerebral cortex: 15 nTPM
- midbrain: 15 nTPM
- basal ganglia: 12 nTPM
- hypothalamus: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.78
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.58
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- phospholipid metabolic process
- phospholipid transport
- positive regulation of ERK1 and ERK2 cascade
- regulation of apoptotic process
- 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TNFAIP8L3 as an antibody target. Whether an autoantibody or antibody against TNFAIP8L3 could matter depends on whether native TNFAIP8L3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TNFAIP8L3 is annotated at the cell surface, where native TNFAIP8L3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TNFAIP8L3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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