Seroatlas · Human Serome Atlas

TNFAIP8

Tumor necrosis factor alpha-induced protein 8

Also known as: GG2-1, MDC-3.13, SCC-S2, TFIP8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95379
Gene: TNFAIP8
Ensembl: ENSG00000145779
Chromosome: 5
Canonical length: 198 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in positive regulation of apoptotic process. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>O95379|TNFAIP8
     1  MHSEAEESKE VATDVFNSKN LAVQAQKKIL GKMVSKSIAT TLIDDTSSEV LDELYRVTRE
    61  YTQNKKEAEK IIKNLIKTVI KLAILYRNNQ FNQDELALME KFKKKVHQLA MTVVSFHQVD
   121  YTFDRNVLSR LLNECREMLH QIIQRHLTAK SHGRVNNVFD HFSDCEFLAA LYNPFGNFKP
   181  HLQKLCDGIN KMLDEENI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFAIP8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 110 nTPM

Expression across tissuesHPA

Tissue

lymph node: 110 nTPM
tonsil: 109 nTPM
thymus: 93 nTPM
adipose tissue: 68 nTPM
bone marrow: 62 nTPM
appendix: 59 nTPM

Single-cell type

neutrophil progenitors: 2,118 nCPM
pancreatic acinar cells: 1,069 nCPM
neutrophils: 732 nCPM
syncytiotrophoblasts: 669 nCPM
monocytes: 665 nCPM
b-cells: 549 nCPM

Immune cell

basophil: 494 nTPM
eosinophil: 306 nTPM
memory B-cell: 268 nTPM
naive CD4 T-cell: 262 nTPM
naive B-cell: 245 nTPM
memory CD4 T-cell: 223 nTPM

Brain region

choroid plexus: 87 nTPM
cerebellum: 38 nTPM
white matter: 34 nTPM
cerebral cortex: 34 nTPM
medulla oblongata: 32 nTPM
thalamus: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0.38
gnomAD missense Z: 0.45
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNFAIP8 as an antibody target. Whether an autoantibody or antibody against TNFAIP8 could matter depends on whether native TNFAIP8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNFAIP8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TNFAIP8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...