Seroatlas · Human Serome Atlas

TMTC1

Protein O-mannosyl-transferase TMTC1

Also known as: ARG99, FLJ31400, FLJ41625, OLF, TMTC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IUR5
Gene
TMTC1
Ensembl
ENSG00000133687
Chromosome
12
Canonical length
882 aa
Protein class
Enzymes, Predicted membrane proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables dolichyl-phosphate-mannose-protein mannosyltransferase activity. Involved in protein O-linked mannosylation. Predicted to be located in endoplasmic reticulum and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

882 residues, UniProt reviewed canonical sequence.

>Q8IUR5|TMTC1
     1  MVVTTSARGG GGDRTPSRRR GCGLAPAGAA ALLAGASCLC YGRSLQGEFV HDDVWAIVNN
    61  PDVRPGAPLR WGIFTNDFWG KGMAENTSHK SYRPLCVLTF KLNIFLTGMN PFYFHAVNII
   121  LHCLVTLVLM YTCDKTVFKN RGLAFVTALL FAVHPIHTEA VAGIVGRADV LACLLFLLAF
   181  LSYNRSLDQG CVGGSFPSTV SPFFLLLSLF LGTCAMLVKE TGITVFGVCL VYDLFSLSNK
   241  QDKSSNGALC PRSPQQPGSP QPSSLPGHPH RENGKQQRFP HKGAWGGCHS PLPPEPKSSG
   301  FPVSPRAVWS MMRFLTYSYL LAFNVWLLLA PVTLCYDWQV GSIPLVETIW DMRNLATIFL
   361  AVVMALLSLH CLAAFKRLEH KEVLVGLLFL VFPFIPASNL FFRVGFVVAE RVLYMPSMGY
   421  CILFVHGLSK LCTWLNRCGA TTLIVSTVLL LLLFSWKTVK QNEIWLSRES LFRSGVQTLP
   481  HNAKVHYNYA NFLKDQGRNK EAIYHYRTAL KLYPRHASAL NNLGTLTRDT AEAKMYYQRA
   541  LQLHPQHNRA LFNLGNLLKS QEKKEEAITL LKDSIKYGPE FADAYSSLAS LLAEQERFKE
   601  AEEIYQTGIK NCPDSSDLHN NYGVFLVDTG LPEKAVAHYQ QAIKLSPSHH VAMVNLGRLY
   661  RSLGENSMAE EWYKRALQVA HKAEILSPLG ALYYNTGRYE EALQIYQEAA ALQPSQRELR
   721  LALAQVLAVM GQTKEAEKMT NHIVSEETGC LECYRLLSAI YSKQENHDKA LDAIDKALQL
   781  KPKDPKVISE LFFTKGNQLR EQNLLDKAFE SYRVAVQLNP DQAQAWMNMG GIQHIKGKYV
   841  SARAYYERAL QLVPDSKLLK ENLAKLDRLE KRLQEVREKD QT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMTC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 34 nTPM
  • blood vessel: 34 nTPM
  • adipose tissue: 29 nTPM
  • tongue: 25 nTPM
  • parathyroid gland: 23 nTPM
  • skeletal muscle: 16 nTPM

Single-cell type

  • vascular endothelial cells: 722 nCPM
  • myonuclei: 512 nCPM
  • lymphatic endothelial cells: 462 nCPM
  • myosatellite cells: 428 nCPM
  • somatotrophs: 425 nCPM
  • gonadotrophs: 409 nCPM

Immune cell

  • non-classical monocyte: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • midbrain: 56 nTPM
  • hypothalamus: 54 nTPM
  • thalamus: 49 nTPM
  • basal ganglia: 47 nTPM
  • hippocampal formation: 46 nTPM
  • pons: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0
gnomAD missense Z
0.71
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMTC1 as an antibody target. Whether an autoantibody or antibody against TMTC1 could matter depends on whether native TMTC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMTC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMTC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMTC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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