Seroatlas · Human Serome Atlas

TMT1B

Thiol S-methyltransferase TMT1B

Also known as: ALDI, METTL7B, MGC17301, TMT1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UX53
Gene: TMT1B
Ensembl: ENSG00000170439
Chromosome: 12
Canonical length: 244 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Vesicles,Microtubules

OverviewNCBI Gene

Enables thiol S-methyltransferase activity. Predicted to be involved in methylation. Predicted to be located in cytosol; endoplasmic reticulum membrane; and lipid droplet. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>Q6UX53|TMT1B
     1  MDILVPLLQL LVLLLTLPLH LMALLGCWQP LCKSYFPYLM AVLTPKSNRK MESKKRELFS
    61  QIKGLTGASG KVALLELGCG TGANFQFYPP GCRVTCLDPN PHFEKFLTKS MAENRHLQYE
   121  RFVVAPGEDM RQLADGSMDV VVCTLVLCSV QSPRKVLQEV RRVLRPGGVL FFWEHVAEPY
   181  GSWAFMWQQV FEPTWKHIGD GCCLTRETWK DLENAQFSEI QMERQPPPLK WLPVGPHIMG
   241  KAVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMT1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 267 nTPM

Expression across tissuesHPA

Tissue

liver: 267 nTPM
heart muscle: 136 nTPM
epididymis: 126 nTPM
duodenum: 57 nTPM
small intestine: 53 nTPM
kidney: 49 nTPM

Single-cell type

enterocytes: 182 nCPM
hofbauer cells: 167 nCPM
epididymal principal cells: 136 nCPM
hepatocytes: 93 nCPM
epididymal efferent duct absorptive cells: 86 nCPM
pituicytes/fscs: 37 nCPM

Immune cell

myeloid DC: 7 nTPM
intermediate monocyte: 4.5 nTPM
non-classical monocyte: 3.3 nTPM
naive B-cell: 1.7 nTPM
classical monocyte: 0.8 nTPM
memory B-cell: 0.5 nTPM

Brain region

hippocampal formation: 19 nTPM
thalamus: 17 nTPM
cerebral cortex: 15 nTPM
medulla oblongata: 9.4 nTPM
white matter: 8.3 nTPM
hypothalamus: 4.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0.07
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

methylation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMT1B as an antibody target. Whether an autoantibody or antibody against TMT1B could matter depends on whether native TMT1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMT1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMT1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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