Seroatlas · Human Serome Atlas

TMPRSS9

Transmembrane protease serine 9

Also known as: TMPS9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z410
Gene: TMPRSS9
Ensembl: ENSG00000178297
Chromosome: 19
Canonical length: 1059 aa
Protein class: Enzymes, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a membrane-bound type II serine polyprotease that is cleaved to release three different proteases. Two of the proteases are active and can be inhibited by serine protease inhibitors, and one is thought to be catalytically inactive. This gene enhances the invasive capability of pancreatic cancer cells and may be involved in cancer progression. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

1059 residues, UniProt reviewed canonical sequence.

>Q7Z410|TMPRSS9
     1  MEPTVADVHL VPRTTKEVPA LDAACCRAAS IGVVATSLVV LTLGVLLAFL STQGFHVDHT
    61  AELRGIRWTS SLRRETSDYH RTLTPTLEAL LHFLLRPLQT LSLGLEEELL QRGIRARLRE
   121  HGISLAAYGT IVSAELTGRH KGPLAERDFK SGRCPGNSFS CGNSQCVTKV NPECDDQEDC
   181  SDGSDEAHCE CGLQPAWRMA GRIVGGMEAS PGEFPWQASL RENKEHFCGA AIINARWLVS
   241  AAHCFNEFQD PTKWVAYVGA TYLSGSEAST VRAQVVQIVK HPLYNADTAD FDVAVLELTS
   301  PLPFGRHIQP VCLPAATHIF PPSKKCLISG WGYLKEDFLV KPEVLQKATV ELLDQALCAS
   361  LYGHSLTDRM VCAGYLDGKV DSCQGDSGGP LVCEEPSGRF FLAGIVSWGI GCAEARRPGV
   421  YARVTRLRDW ILEATTKASM PLAPTMAPAP AAPSTAWPTS PESPVVSTPT KSMQALSTVP
   481  LDWVTVPKLQ ECGARPAMEK PTRVVGGFGA ASGEVPWQVS LKEGSRHFCG ATVVGDRWLL
   541  SAAHCFNHTK VEQVRAHLGT ASLLGLGGSP VKIGLRRVVL HPLYNPGILD FDLAVLELAS
   601  PLAFNKYIQP VCLPLAIQKF PVGRKCMISG WGNTQEGNAT KPELLQKASV GIIDQKTCSV
   661  LYNFSLTDRM ICAGFLEGKV DSCQGDSGGP LACEEAPGVF YLAGIVSWGI GCAQVKKPGV
   721  YTRITRLKGW ILEIMSSQPL PMSPPSTTRM LATTSPRTTA GLTVPGATPS RPTPGAASRV
   781  TGQPANSTLS AVSTTARGQT PFPDAPEATT HTQLPDCGLA PAALTRIVGG SAAGRGEWPW
   841  QVSLWLRRRE HRCGAVLVAE RWLLSAAHCF DVYGDPKQWA AFLGTPFLSG AEGQLERVAR
   901  IYKHPFYNLY TLDYDVALLE LAGPVRRSRL VRPICLPEPA PRPPDGTRCV ITGWGSVREG
   961  GSMARQLQKA AVRLLSEQTC RRFYPVQISS RMLCAGFPQG GVDSCSGDAG GPLACREPSG
  1021  RWVLTGVTSW GYGCGRPHFP GVYTRVAAVR GWIGQHIQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMPRSS9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 4.1 nTPM

Expression across tissuesHPA

Tissue

liver: 4.1 nTPM
testis: 3.6 nTPM
spleen: 2.2 nTPM
bone marrow: 0.7 nTPM
adrenal gland: 0.6 nTPM
pancreas: 0.6 nTPM

Single-cell type

late spermatids: 116 nCPM
breast myoepithelial cells: 54 nCPM
epicardial cells: 41 nCPM
myonuclei: 36 nCPM
granulosa cells: 33 nCPM
late primary spermatocytes: 32 nCPM

Immune cell

eosinophil: 0.4 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

amygdala: 5.5 nTPM
cerebral cortex: 5 nTPM
cerebellum: 4 nTPM
pons: 4 nTPM
thalamus: 3.7 nTPM
medulla oblongata: 3.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMPRSS9.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 304 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Global developmental delay
TMPRSS9-related neurodevelopmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: -1.22
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

plasminogen activation

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMPRSS9 as an antibody target. Whether an autoantibody or antibody against TMPRSS9 could matter depends on whether native TMPRSS9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMPRSS9 is annotated at the cell surface, where native TMPRSS9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMPRSS9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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