Seroatlas · Human Serome Atlas

TMPRSS7

Transmembrane protease serine 7

Also known as: TMPS7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7RTY8
Gene
TMPRSS7
Ensembl
ENSG00000176040
Chromosome
3
Canonical length
843 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable serine-type peptidase activity. Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

843 residues, UniProt reviewed canonical sequence.

>Q7RTY8|TMPRSS7
     1  MDKENSDVSA APADLKISNI SVQVVSAQKK LPVRRPPLPG RRLPLPGRRP PQRPIGKAKP
    61  KKQSKKKVPF WNVQNKIILF TVFLFILAVI AWTLLWLYIS KTESKDAFYF AGMFRITNIE
   121  FLPEYRQKES REFLSVSRTV QQVINLVYTT SAFSKFYEQS VVADVSSNNK GGLLVHFWIV
   181  FVMPRAKGHI FCEDCVAAIL KDSIQTSIIN RTSVGSLQGL AVDMDSVVLN AGLRSDYSST
   241  IGSDKGCSQY FYAEHLSLHY PLEISAASGR LMCHFKLVAI VGYLIRLSIK SIQIEADNCV
   301  TDSLTIYDSL LPIRSSILYR ICEPTRTLMS FVSTNNLMLV TFKSPHIRRL SGIRAYFEVI
   361  PEQKCENTVL VKDITGFEGK ISSPYYPSYY PPKCKCTWKF QTSLSTLGIA LKFYNYSITK
   421  KSMKGCEHGW WEINEHMYCG SYMDHQTIFR VPSPLVHIQL QCSSRLSDKP LLAEYGSYNI
   481  SQPCPVGSFR CSSGLCVPQA QRCDGVNDCF DESDELFCVS PQPACNTSSF RQHGPLICDG
   541  FRDCENGRDE QNCTQSIPCN NRTFKCGNDI CFRKQNAKCD GTVDCPDGSD EEGCTCSRSS
   601  SALHRIIGGT DTLEGGWPWQ VSLHFVGSAY CGASVISREW LLSAAHCFHG NRLSDPTPWT
   661  AHLGMYVQGN AKFVSPVRRI VVHEYYNSQT FDYDIALLQL SIAWPETLKQ LIQPICIPPT
   721  GQRVRSGEKC WVTGWGRRHE ADNKGSLVLQ QAEVELIDQT LCVSTYGIIT SRMLCAGIMS
   781  GKRDACKGDS GGPLSCRRKS DGKWILTGIV SWGHGSGRPN FPGVYTRVSN FVPWIHKYVP
   841  SLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMPRSS7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
1.3 nTPM

Expression across tissuesHPA

Tissue

  • testis: 1.3 nTPM
  • fallopian tube: 0.3 nTPM
  • choroid plexus: 0.2 nTPM
  • small intestine: 0.2 nTPM
  • stomach: 0.2 nTPM
  • thymus: 0.2 nTPM

Single-cell type

  • late primary spermatocytes: 18 nCPM
  • respiratory ciliated cells: 14 nCPM
  • goblet cells: 8.3 nCPM
  • corticotrophs: 7.6 nCPM
  • fallopian tube ciliated cells: 6.4 nCPM
  • early spermatids: 6.2 nCPM

Immune cell

  • basophil: 0.5 nTPM
  • neutrophil: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • memory B-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM

Brain region

  • choroid plexus: 1 nTPM
  • cerebellum: 0.9 nTPM
  • cerebral cortex: 0.7 nTPM
  • basal ganglia: 0.6 nTPM
  • spinal cord: 0.6 nTPM
  • white matter: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.1
gnomAD pLI
0
gnomAD missense Z
0.4
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMPRSS7 as an antibody target. Whether an autoantibody or antibody against TMPRSS7 could matter depends on whether native TMPRSS7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMPRSS7 is annotated at the cell surface, where native TMPRSS7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMPRSS7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMPRSS7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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