Seroatlas · Human Serome Atlas

TMPRSS5

Transmembrane protease serine 5

Also known as: MGC141886, MGC148044, TMPS5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H3S3
Gene: TMPRSS5
Ensembl: ENSG00000166682
Chromosome: 11
Canonical length: 457 aa
Protein class: Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein that belongs to the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Canonical amino-acid sequenceUniProt

457 residues, UniProt reviewed canonical sequence.

>Q9H3S3|TMPRSS5
     1  MSLMLDDQPP MEAQYAEEGP GPGIFRAEPG DQQHPISQAV CWRSMRRGCA VLGALGLLAG
    61  AGVGSWLLVL YLCPAASQPI SGTLQDEEIT LSCSEASAEE ALLPALPKTV SFRINSEDFL
   121  LEAQVRDQPR WLLVCHEGWS PALGLQICWS LGHLRLTHHK GVNLTDIKLN SSQEFAQLSP
   181  RLGGFLEEAW QPRNNCTSGQ VVSLRCSECG ARPLASRIVG GQSVAPGRWP WQASVALGFR
   241  HTCGGSVLAP RWVVTAAHCM HSFRLARLSS WRVHAGLVSH SAVRPHQGAL VERIIPHPLY
   301  SAQNHDYDVA LLRLQTALNF SDTVGAVCLP AKEQHFPKGS RCWVSGWGHT HPSHTYSSDM
   361  LQDTVVPLFS TQLCNSSCVY SGALTPRMLC AGYLDGRADA CQGDSGGPLV CPDGDTWRLV
   421  GVVSWGRGCA EPNHPGVYAK VAEFLDWIHD TAQDSLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMPRSS5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

midbrain: 17 nTPM
basal ganglia: 17 nTPM
hippocampal formation: 15 nTPM
spinal cord: 15 nTPM
amygdala: 15 nTPM
salivary gland: 9.5 nTPM

Single-cell type

salivary acinar cells: 48 nCPM
schwann cells: 41 nCPM
astrocytes: 39 nCPM
ependymal cells: 39 nCPM
salivary myoepithelial cells: 29 nCPM
oligodendrocytes: 27 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 61 nTPM
cerebral cortex: 35 nTPM
basal ganglia: 31 nTPM
medulla oblongata: 30 nTPM
thalamus: 26 nTPM
midbrain: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 0.92
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMPRSS5 as an antibody target. Whether an autoantibody or antibody against TMPRSS5 could matter depends on whether native TMPRSS5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMPRSS5 is annotated at the cell surface, where native TMPRSS5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMPRSS5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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