Seroatlas · Human Serome Atlas

TMPRSS4

Transmembrane protease serine 4

Also known as: CAP2, MT-SP2, TMPRSS3, TMPS4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRS4
Gene: TMPRSS4
Ensembl: ENSG00000137648
Chromosome: 11
Canonical length: 437 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. The protein has been found to promote SARS-CoV-2 entry into host cells. [provided by RefSeq, Aug 2021]

Canonical amino-acid sequenceUniProt

437 residues, UniProt reviewed canonical sequence.

>Q9NRS4|TMPRSS4
     1  MLQDPDSDQP LNSLDVKPLR KPRIPMETFR KVGIPIIIAL LSLASIIIVV VLIKVILDKY
    61  YFLCGQPLHF IPRKQLCDGE LDCPLGEDEE HCVKSFPEGP AVAVRLSKDR STLQVLDSAT
   121  GNWFSACFDN FTEALAETAC RQMGYSSKPT FRAVEIGPDQ DLDVVEITEN SQELRMRNSS
   181  GPCLSGSLVS LHCLACGKSL KTPRVVGVEE ASVDSWPWQV SIQYDKQHVC GGSILDPHWV
   241  LTAAHCFRKH TDVFNWKVRA GSDKLGSFPS LAVAKIIIIE FNPMYPKDND IALMKLQFPL
   301  TFSGTVRPIC LPFFDEELTP ATPLWIIGWG FTKQNGGKMS DILLQASVQV IDSTRCNADD
   361  AYQGEVTEKM MCAGIPEGGV DTCQGDSGGP LMYQSDQWHV VGIVSWGYGC GGPSTPGVYT
   421  KVSAYLNWIY NVWKAEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMPRSS4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 82 nTPM

Expression across tissuesHPA

Tissue

esophagus: 82 nTPM
urinary bladder: 70 nTPM
colon: 41 nTPM
rectum: 40 nTPM
stomach: 30 nTPM
duodenum: 24 nTPM

Single-cell type

prostatic hillock cells: 800 nCPM
esophageal apical cells: 549 nCPM
ocular epithelial cells: 543 nCPM
urothelial cells: 535 nCPM
respiratory basal cells: 446 nCPM
salivary duct cells: 443 nCPM

Immune cell

basophil: 2 nTPM
neutrophil: 0.3 nTPM
non-classical monocyte: 0.2 nTPM
eosinophil: 0.1 nTPM
naive B-cell: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 6.4 nTPM
choroid plexus: 3.5 nTPM
cerebral cortex: 3.4 nTPM
white matter: 3.4 nTPM
pons: 3.2 nTPM
hippocampal formation: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: 0.35
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of viral entry into host cell
protein processing
proteolysis
regulation of gene expression
response to wounding
negative regulation of growth rate

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMPRSS4 as an antibody target. Whether an autoantibody or antibody against TMPRSS4 could matter depends on whether native TMPRSS4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMPRSS4 is annotated at the cell surface, where native TMPRSS4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMPRSS4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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