Seroatlas · Human Serome Atlas

TMPRSS3

Transmembrane protease serine 3

Also known as: DFNB10, DFNB8, TMPS3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P57727
Gene
TMPRSS3
Ensembl
ENSG00000160183
Chromosome
21
Canonical length
454 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

454 residues, UniProt reviewed canonical sequence.

>P57727|TMPRSS3
     1  MGENDPPAVE APFSFRSLFG LDDLKISPVA PDADAVAAQI LSLLPLKFFP IIVIGIIALI
    61  LALAIGLGIH FDCSGKYRCR SSFKCIELIA RCDGVSDCKD GEDEYRCVRV GGQNAVLQVF
   121  TAASWKTMCS DDWKGHYANV ACAQLGFPSY VSSDNLRVSS LEGQFREEFV SIDHLLPDDK
   181  VTALHHSVYV REGCASGHVV TLQCTACGHR RGYSSRIVGG NMSLLSQWPW QASLQFQGYH
   241  LCGGSVITPL WIITAAHCVY DLYLPKSWTI QVGLVSLLDN PAPSHLVEKI VYHSKYKPKR
   301  LGNDIALMKL AGPLTFNEMI QPVCLPNSEE NFPDGKVCWT SGWGATEDGA GDASPVLNHA
   361  AVPLISNKIC NHRDVYGGII SPSMLCAGYL TGGVDSCQGD SGGPLVCQER RLWKLVGATS
   421  FGIGCAEVNK PGVYTRVTSF LDWIHEQMER DLKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMPRSS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 22 nTPM
  • stomach: 14 nTPM
  • salivary gland: 8.6 nTPM
  • breast: 8.2 nTPM
  • gallbladder: 8.1 nTPM
  • cervix: 5.9 nTPM

Single-cell type

  • fallopian tube ciliated cells: 89 nCPM
  • foveolar cells: 39 nCPM
  • breast lactating cells: 37 nCPM
  • salivary ionocytes: 37 nCPM
  • mucous neck cells: 36 nCPM
  • respiratory ciliated cells: 36 nCPM

Immune cell

  • MAIT T-cell: 3.2 nTPM
  • memory CD8 T-cell: 1.8 nTPM
  • memory CD4 T-cell: 1.7 nTPM
  • naive CD8 T-cell: 0.9 nTPM
  • gdT-cell: 0.8 nTPM
  • T-reg: 0.8 nTPM

Brain region

  • medulla oblongata: 6.2 nTPM
  • midbrain: 5.9 nTPM
  • thalamus: 5.6 nTPM
  • cerebellum: 4.3 nTPM
  • hypothalamus: 4.3 nTPM
  • basal ganglia: 4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMPRSS3.

Disease | AllUniProt

Conditions TMPRSS3 is implicated in, by any mechanism.

  • Deafness, autosomal recessive, 8 (DFNB8) MIM:601072

Disease | GeneticClinVar

117 pathogenic / likely-pathogenic of 671 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
-0.57
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMPRSS3 as an antibody target. Whether an autoantibody or antibody against TMPRSS3 could matter depends on whether native TMPRSS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMPRSS3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMPRSS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMPRSS3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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