Seroatlas · Human Serome Atlas

TMPRSS15

Enteropeptidase

Also known as: ENTK, ENTK_HUMAN, MGC133046, PRSS7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P98073
Gene: TMPRSS15
Ensembl: ENSG00000154646
Chromosome: 21
Canonical length: 1019 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1019 residues, UniProt reviewed canonical sequence.

>P98073|TMPRSS15
     1  MGSKRGISSR HHSLSSYEIM FAALFAILVV LCAGLIAVSC LTIKESQRGA ALGQSHEARA
    61  TFKITSGVTY NPNLQDKLSV DFKVLAFDLQ QMIDEIFLSS NLKNEYKNSR VLQFENGSII
   121  VVFDLFFAQW VSDENVKEEL IQGLEANKSS QLVTFHIDLN SVDILDKLTT TSHLATPGNV
   181  SIECLPGSSP CTDALTCIKA DLFCDGEVNC PDGSDEDNKM CATVCDGRFL LTGSSGSFQA
   241  THYPKPSETS VVCQWIIRVN QGLSIKLSFD DFNTYYTDIL DIYEGVGSSK ILRASIWETN
   301  PGTIRIFSNQ VTATFLIESD ESDYVGFNAT YTAFNSSELN NYEKINCNFE DGFCFWVQDL
   361  NDDNEWERIQ GSTFSPFTGP NFDHTFGNAS GFYISTPTGP GGRQERVGLL SLPLDPTLEP
   421  ACLSFWYHMY GENVHKLSIN ISNDQNMEKT VFQKEGNYGD NWNYGQVTLN ETVKFKVAFN
   481  AFKNKILSDI ALDDISLTYG ICNGSLYPEP TLVPTPPPEL PTDCGGPFEL WEPNTTFSST
   541  NFPNSYPNLA FCVWILNAQK GKNIQLHFQE FDLENINDVV EIRDGEEADS LLLAVYTGPG
   601  PVKDVFSTTN RMTVLLITND VLARGGFKAN FTTGYHLGIP EPCKADHFQC KNGECVPLVN
   661  LCDGHLHCED GSDEADCVRF FNGTTNNNGL VRFRIQSIWH TACAENWTTQ ISNDVCQLLG
   721  LGSGNSSKPI FPTDGGPFVK LNTAPDGHLI LTPSQQCLQD SLIRLQCNHK SCGKKLAAQD
   781  ITPKIVGGSN AKEGAWPWVV GLYYGGRLLC GASLVSSDWL VSAAHCVYGR NLEPSKWTAI
   841  LGLHMKSNLT SPQTVPRLID EIVINPHYNR RRKDNDIAMM HLEFKVNYTD YIQPICLPEE
   901  NQVFPPGRNC SIAGWGTVVY QGTTANILQE ADVPLLSNER CQQQMPEYNI TENMICAGYE
   961  EGGIDSCQGD SGGPLMCQEN NRWFLAGVTS FGYKCALPNR PGVYARVSRF TEWIQSFLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMPRSS15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 922 nTPM

Expression across tissuesHPA

Tissue

duodenum: 922 nTPM
small intestine: 21 nTPM
testis: 0.9 nTPM
lymph node: 0.6 nTPM
stomach: 0.3 nTPM
appendix: 0.2 nTPM

Single-cell type

enterocytes: 51 nCPM
enteric transient amplifying cells: 29 nCPM
adrenal medulla cells: 11 nCPM
early spermatids: 7.7 nCPM
retinal ganglion cells: 7.7 nCPM
foveolar cells: 5.2 nCPM

Immune cell

naive B-cell: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 8.3 nTPM
cerebral cortex: 7.9 nTPM
white matter: 7.4 nTPM
amygdala: 6.4 nTPM
basal ganglia: 6.2 nTPM
hippocampal formation: 6.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMPRSS15.

Disease | AllUniProt

Conditions TMPRSS15 is implicated in, by any mechanism.

Enterokinase deficiency (ENTKD) MIM:226200

Disease | GeneticClinVar

79 pathogenic / likely-pathogenic of 671 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Enterokinase deficiency
TMPRSS15-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: -0.86
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMPRSS15 as an antibody target. Whether an autoantibody or antibody against TMPRSS15 could matter depends on whether native TMPRSS15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMPRSS15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMPRSS15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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