Seroatlas · Human Serome Atlas

TMPRSS13

Transmembrane protease serine 13

Also known as: MSPL, MSPS, TMPRSS11, TMPSD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BYE2
Gene: TMPRSS13
Ensembl: ENSG00000137747
Chromosome: 11
Canonical length: 586 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Plasma membrane
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene encodes a member of the type II transmembrane serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Transmembrane serine proteases are regulated by protease inhibitors and known to function in development, homeostasis, infection, and tumorigenesis. This protein facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. [provided by RefSeq, Aug 2021]

Canonical amino-acid sequenceUniProt

586 residues, UniProt reviewed canonical sequence.

>Q9BYE2|TMPRSS13
     1  MERDSHGNAS PARTPSAGAS PAQASPAGTP PGRASPAQAS PAQASPAGTP PGRASPAQAS
    61  PAGTPPGRAS PGRASPAQAS PAQASPARAS PALASLSRSS SGRSSSARSA SVTTSPTRVY
   121  LVRATPVGAV PIRSSPARSA PATRATRESP GTSLPKFTWR EGQKQLPLIG CVLLLIALVV
   181  SLIILFQFWQ GHTGIRYKEQ RESCPKHAVR CDGVVDCKLK SDELGCVRFD WDKSLLKIYS
   241  GSSHQWLPIC SSNWNDSYSE KTCQQLGFES AHRTTEVAHR DFANSFSILR YNSTIQESLH
   301  RSECPSQRYI SLQCSHCGLR AMTGRIVGGA LASDSKWPWQ VSLHFGTTHI CGGTLIDAQW
   361  VLTAAHCFFV TREKVLEGWK VYAGTSNLHQ LPEAASIAEI IINSNYTDEE DDYDIALMRL
   421  SKPLTLSAHI HPACLPMHGQ TFSLNETCWI TGFGKTRETD DKTSPFLREV QVNLIDFKKC
   481  NDYLVYDSYL TPRMMCAGDL RGGRDSCQGD SGGPLVCEQN NRWYLAGVTS WGTGCGQRNK
   541  PGVYTKVTEV LPWIYSKMEV RSLQQDTAPS RLGTSSGGDP GGAPRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMPRSS13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

skin: 37 nTPM
esophagus: 14 nTPM
salivary gland: 10 nTPM
vagina: 8.5 nTPM
breast: 6.6 nTPM
cervix: 6.3 nTPM

Single-cell type

esophageal apical cells: 98 nCPM
salivary ionocytes: 45 nCPM
esophageal suprabasal cells: 39 nCPM
respiratory ionocytes: 31 nCPM
migrating cytotrophoblasts: 30 nCPM
extravillous trophoblasts: 28 nCPM

Immune cell

plasmacytoid DC: 0.5 nTPM
NK-cell: 0.4 nTPM
myeloid DC: 0.3 nTPM
basophil: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
total PBMC: 0.2 nTPM

Brain region

hippocampal formation: 3.6 nTPM
cerebral cortex: 3.1 nTPM
amygdala: 2.1 nTPM
basal ganglia: 2.1 nTPM
white matter: 2.1 nTPM
hypothalamus: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 1.01
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMPRSS13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMPRSS13 as an antibody target. Whether an autoantibody or antibody against TMPRSS13 could matter depends on whether native TMPRSS13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMPRSS13 is annotated at the cell surface, where native TMPRSS13 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMPRSS13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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