Seroatlas · Human Serome Atlas

TMPRSS12

Transmembrane protease serine 12

Also known as: CT151, MGC57341, TMPSC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86WS5
Gene: TMPRSS12
Ensembl: ENSG00000186452
Chromosome: 12
Canonical length: 348 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in acrosome assembly and positive regulation of sperm capacitation. Predicted to act upstream of or within binding activity of sperm to zona pellucida and protein processing. Predicted to be located in acrosomal vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

348 residues, UniProt reviewed canonical sequence.

>Q86WS5|TMPRSS12
     1  MRLGLLSVAL LFVGSSHLYS DHYSPSGRHR LGPSPEPAAS SQQAEAVRKR LRRRREGGAH
    61  AEDCGTAPLK DVLQGSRIIG GTEAQAGAWP WVVSLQIKYG RVLVHVCGGT LVRERWVLTA
   121  AHCTKDASDP LMWTAVIGTN NIHGRYPHTK KIKIKAIIIH PNFILESYVN DIALFHLKKA
   181  VRYNDYIQPI CLPFDVFQIL DGNTKCFISG WGRTKEEGNA TNILQDAEVH YISREMCNSE
   241  RSYGGIIPNT SFCAGDEDGA FDTCRGDSGG PLMCYLPEYK RFFVMGITSY GHGCGRRGFP
   301  GVYIGPSFYQ KWLTEHFFHA STQGILTINI LRGQILIALC FVILLATT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMPRSS12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

testis: 20 nTPM
epididymis: 0.4 nTPM
breast: 0.1 nTPM
kidney: 0.1 nTPM
retina: 0.1 nTPM
skin: 0.1 nTPM

Single-cell type

late primary spermatocytes: 271 nCPM
early primary spermatocytes: 35 nCPM
early spermatids: 25 nCPM
pdcs: 12 nCPM
epicardial cells: 9.1 nCPM
retinal ganglion cells: 7.7 nCPM

Immune cell

basophil: 0.2 nTPM
neutrophil: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 2 nTPM
choroid plexus: 1.8 nTPM
cerebral cortex: 1.5 nTPM
white matter: 1.5 nTPM
hypothalamus: 1.3 nTPM
medulla oblongata: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: 0
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMPRSS12 as an antibody target. Whether an autoantibody or antibody against TMPRSS12 could matter depends on whether native TMPRSS12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMPRSS12 is annotated at the cell surface, where native TMPRSS12 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMPRSS12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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