Seroatlas · Human Serome Atlas

TMIGD3

Transmembrane domain-containing protein TMIGD3

Also known as: AD026, TMIG3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DMS9
Gene
TMIGD3
Ensembl
ENSG00000121933
Chromosome
1
Canonical length
266 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 5' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:140), thus resulting in a fusion product. [provided by RefSeq, Nov 2014]

Canonical amino-acid sequenceUniProt

266 residues, UniProt reviewed canonical sequence.

>P0DMS9|TMIGD3
     1  MEGSPAGPIE QKEARWESSW EEQPDWTLGC LSPESQFRIP GLPGCILSFQ LKVCFLPVMW
    61  LFILLSLALI SDAMVMDEKV KRSFVLDTAS AICNYNAHYK NHPKYWCRGY FRDYCNIIAF
   121  SPNSTNHVAL RDTGNQLIVT MSCLTKEDTG WYWCGIQRDF ARDDMDFTEL IVTDDKGTLA
   181  NDFWSGKDLS GNKTRSCKAP KVVRKADRSR TSILIICILI TGLGIISVIS HLTKRRRSQR
   241  NRRVGNTLKP FSRVLTPKEM APTEQM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMIGD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
52 nTPM

Expression across tissuesHPA

Tissue

  • testis: 52 nTPM
  • placenta: 4.3 nTPM
  • adrenal gland: 3.2 nTPM
  • liver: 2.4 nTPM
  • cerebral cortex: 2 nTPM
  • bone marrow: 1.9 nTPM

Single-cell type

  • hofbauer cells: 525 nCPM
  • late primary spermatocytes: 478 nCPM
  • kupffer cells: 365 nCPM
  • early spermatids: 249 nCPM
  • microglia: 153 nCPM
  • late spermatids: 143 nCPM

Immune cell

  • eosinophil: 63 nTPM
  • classical monocyte: 1.4 nTPM
  • neutrophil: 1.4 nTPM
  • plasmacytoid DC: 0.6 nTPM
  • total PBMC: 0.6 nTPM
  • myeloid DC: 0.5 nTPM

Brain region

  • white matter: 14 nTPM
  • pons: 11 nTPM
  • medulla oblongata: 11 nTPM
  • thalamus: 9.1 nTPM
  • cerebral cortex: 7.9 nTPM
  • spinal cord: 7.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect
-0.05
DepMap dependency class
none

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMIGD3 as an antibody target. Whether an autoantibody or antibody against TMIGD3 could matter depends on whether native TMIGD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMIGD3 is annotated at the cell surface, where native TMIGD3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMIGD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMIGD3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...