Seroatlas · Human Serome Atlas

TMIGD1

Transmembrane and immunoglobulin domain-containing protein 1

Also known as: TMIG1_HUMAN, TMIGD, UNQ9372

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UXZ0
Gene: TMIGD1
Ensembl: ENSG00000182271
Chromosome: 17
Canonical length: 262 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Mitochondria,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable cell-cell adhesion mediator activity and protein homodimerization activity. Involved in several processes, including negative regulation of apoptotic process; regulation of cell migration; and regulation of membrane permeability. Located in cytosol; mitochondrion; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>Q6UXZ0|TMIGD1
     1  MAWKSSVIMQ MGRFLLLVIL FLPREMTSSV LTVNGKTENY ILDTTPGSQA SLICAVQNHT
    61  REEELLWYRE EGRVDLKSGN KINSSSVCVS SISENDNGIS FTCRLGRDQS VSVSVVLNVT
   121  FPPLLSGNDF QTVEEGSNVK LVCNVKANPQ AQMMWYKNSS LLDLEKSRHQ IQQTSESFQL
   181  SITKVEKPDN GTYSCIAKSS LKTESLDFHL IVKDKTVGVP IEPIIAACVV IFLTLCFGLI
   241  ARRKKIMKLC MKDKDPHSET AL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMIGD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 132 nTPM

Expression across tissuesHPA

Tissue

small intestine: 132 nTPM
rectum: 93 nTPM
colon: 76 nTPM
kidney: 4.5 nTPM
smooth muscle: 0.9 nTPM
appendix: 0.3 nTPM

Single-cell type

enterocytes: 805 nCPM
colonocytes: 305 nCPM
enteric transient amplifying cells: 21 nCPM
paneth cells: 16 nCPM
goblet cells: 7.8 nCPM
hepatic stellate cells: 6.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0
gnomAD missense Z: -0.73
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMIGD1 as an antibody target. Whether an autoantibody or antibody against TMIGD1 could matter depends on whether native TMIGD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMIGD1 is annotated at the cell surface, where native TMIGD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMIGD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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