TMEM98

Protein identityUniProt · HPA

UniProt accession

Q9Y2Y6

Gene

TMEM98

Ensembl

ENSG00000006042

Chromosome

17

Canonical length

226 aa

Protein class

Disease related genes, Human disease related genes, Predicted membrane proteins

Subcellular location

Nucleoplasm

Secretome location

Intracellular and membrane

OverviewNCBI Gene

This gene encodes a transmembrane protein. A missense mutation in this gene result in Nanophthalmos 4 (NNO4). Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

226 residues, UniProt reviewed canonical sequence.

>Q9Y2Y6|TMEM98
     1  METVVIVAIG VLATIFLASF AALVLVCRQR YCRPRDLLQR YDSKPIVDLI GAMETQSEPS
    61  ELELDDVVIT NPHIEAILEN EDWIEDASGL MSHCIAILKI CHTLTEKLVA MTMGSGAKMK
   121  TSASVSDIIV VAKRISPRVD DVVKSMYPPL DPKLLDARTT ALLLSVSHLV LVTRNACHLT
   181  GGLDWIDQSL SAAEEHLEVL REAALASEPD KGLPGPEGFL QEQSAI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM98 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

393 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMEM98.

Disease | AllUniProt

Conditions TMEM98 is implicated in, by any mechanism.

• Nanophthalmos 4 (NNO4) MIM:615972

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 56 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Nanophthalmos 4

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.89

gnomAD pLI

0.01

gnomAD missense Z

0.73

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of myelination
• negative regulation of oligodendrocyte differentiation
• negative regulation of protein localization to nucleus
• negative regulation of protein processing
• T-helper 1 cell differentiation

Cellular components

• endoplasmic reticulum
• endoplasmic reticulum membrane
• extracellular exosome
• extracellular space
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Transmembrane protein 98

KeywordsUniProt

• Cell membrane
• Endoplasmic reticulum
• Membrane
• Secreted
• Transmembrane
• Transmembrane helix