Seroatlas · Human Serome Atlas

TMEM95

Sperm-egg fusion protein TMEM95

Also known as: MGC129793, TMM95_HUMAN, UNQ9390

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3KNT9
Gene: TMEM95
Ensembl: ENSG00000182896
Chromosome: 17
Canonical length: 176 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in cytoplasmic vesicle and sperm plasma membrane. Predicted to be active in acrosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

176 residues, UniProt reviewed canonical sequence.

>Q3KNT9|TMEM95
     1  MWRLALGGVF LAAAQACVFC RLPAHDLSGR LARLCSQMEA RQKECGASPD FSAFALDEVS
    61  MNKVTEKTHR VLRVMEIKEA VSSLPSYWSW LRKTKLPEYT REALCPPACR GSTTLYNCST
   121  CKGTEVSCWP RKRCFPGSQD LWEAKILLLS IFGAFLLLGV LSLLVESHHL QAKSGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM95 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

testis: 10 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late spermatids: 4.3 nCPM
late primary spermatocytes: 4 nCPM
early spermatids: 3.6 nCPM
papillary tip epithelial cells: 0.2 nCPM
oligodendrocytes: 0.1 nCPM
adipocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 1.1 nTPM
cerebral cortex: 0.6 nTPM
white matter: 0.6 nTPM
basal ganglia: 0.4 nTPM
thalamus: 0.4 nTPM
hippocampal formation: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0
gnomAD missense Z: -0.23
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

fusion of sperm to egg plasma membrane involved in single fertilization

Cellular components

Protein domainsUniProt · Pfam · InterPro

TMEM95 family
TMEM95 family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM95 as an antibody target. Whether an autoantibody or antibody against TMEM95 could matter depends on whether native TMEM95 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM95 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM95 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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