TMEM92
Transmembrane protein 92
Also known as: FLJ33318, TMM92_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UXU6
- Gene
- TMEM92
- Ensembl
- ENSG00000167105
- Chromosome
- 17
- Canonical length
- 159 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
159 residues, UniProt reviewed canonical sequence.
>Q6UXU6|TMEM92
1 MSQAWVPGLA PTLLFSLLAG PQKIAAKCGL ILACPKGFKC CGDSCCQENE LFPGPVRIFV
61 IIFLVILSVF CICGLAKCFC RNCREPEPDS PVDCRGPLEL PSIIPPERVR VSLSAPPPPY
121 SEVILKPSLG PTPTEPPPPY SFRPEEYTGD QRGIDNPAFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM92 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.62
- Highest tissue expression
- 18 nTPM
Expression across tissuesHPA
Tissue
- small intestine: 18 nTPM
- duodenum: 15 nTPM
- stomach: 10 nTPM
- liver: 4.4 nTPM
- gallbladder: 4.2 nTPM
- cervix: 2 nTPM
Single-cell type
- enterocytes: 295 nCPM
- breast lactating cells: 116 nCPM
- gastric chief cells: 81 nCPM
- parietal cells: 46 nCPM
- paneth cells: 39 nCPM
- foveolar cells: 36 nCPM
Immune cell
- neutrophil: 0.8 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- medulla oblongata: 1.6 nTPM
- thalamus: 1.4 nTPM
- cerebral cortex: 1.1 nTPM
- pons: 1.1 nTPM
- amygdala: 1 nTPM
- basal ganglia: 0.9 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about TMEM92.
Disease | GeneticClinVar
1 pathogenic / likely-pathogenic of 35 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Global developmental delay
- Cerebellar atrophy
- Bilateral squint
- Hydrocephalus
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.41
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.29
- DepMap mean gene effect
- -0.16
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM92 as an antibody target. Whether an autoantibody or antibody against TMEM92 could matter depends on whether native TMEM92 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM92 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMEM92 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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