Seroatlas · Human Serome Atlas

TMEM89

Transmembrane protein 89

Also known as: TMM89_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A2RUT3
Gene
TMEM89
Ensembl
ENSG00000183396
Chromosome
3
Canonical length
159 aa
Protein class
Predicted membrane proteins
Subcellular location
Perinuclear theca

OverviewNCBI Gene

Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

159 residues, UniProt reviewed canonical sequence.

>A2RUT3|TMEM89
     1  MLHVLASLPL LLLLVTSAST HAWSRPLWYQ VGLDLQPWGC QPKSVEGCRG GLSCPGYWLG
    61  PGASRIYPVA AVMITTTMLM ICRKILQGRR RSQATKGEHP QVTTEPCGPW KRRAPISDHT
   121  LLRGVLHMLD ALLVHIEGHL RHLATQRQIQ IKGTSTQSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM89 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • testis: 28 nTPM
  • bone marrow: 1.6 nTPM
  • blood vessel: 0.5 nTPM
  • colon: 0.5 nTPM
  • small intestine: 0.5 nTPM
  • stomach: 0.4 nTPM

Single-cell type

  • late spermatids: 313 nCPM
  • early spermatids: 306 nCPM
  • late primary spermatocytes: 269 nCPM
  • parietal cells: 1.8 nCPM
  • gastric chief cells: 1.1 nCPM
  • proximal tubule cells: 1.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1.3 nTPM
  • amygdala: 0.7 nTPM
  • cerebellum: 0.7 nTPM
  • hypothalamus: 0.7 nTPM
  • basal ganglia: 0.6 nTPM
  • medulla oblongata: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.62
gnomAD pLI
0.77
gnomAD missense Z
-0.12
DepMap mean gene effect
-0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Transmembrane protein 89
  • TMEM89 protein family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM89 as an antibody target. Whether an autoantibody or antibody against TMEM89 could matter depends on whether native TMEM89 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM89 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM89 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM89. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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