Seroatlas · Human Serome Atlas

TMEM88

Transmembrane protein 88

Also known as: FLJ20025, MGC71744, TMM88_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6PEY1
Gene
TMEM88
Ensembl
ENSG00000167874
Chromosome
17
Canonical length
159 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable PDZ domain binding activity. Involved in negative regulation of canonical Wnt signaling pathway; protein localization to plasma membrane; and protein stabilization. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

159 residues, UniProt reviewed canonical sequence.

>Q6PEY1|TMEM88
     1  MADVPGAQRA VPGDGPEPRD PLDCWACAVL VTAQNLLVAA FNLLLLVLVL GTILLPAVTM
    61  LGFGFLCHSQ FLRSQAPPCT AHLRDPGFTA LLVTGFLLLV PLLVLALASY RRLCLRLRLA
   121  DCLVPYSRAL YRRRRAPQPR QIRASPGSQA VPTSGKVWV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM88 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
98 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 98 nTPM
  • adipose tissue: 60 nTPM
  • thyroid gland: 38 nTPM
  • kidney: 36 nTPM
  • tongue: 34 nTPM
  • skeletal muscle: 33 nTPM

Single-cell type

  • vascular endothelial cells: 143 nCPM
  • lymphatic endothelial cells: 21 nCPM
  • neutrophils: 21 nCPM
  • epididymal basal cells: 15 nCPM
  • late spermatids: 14 nCPM
  • mast cells: 14 nCPM

Immune cell

  • neutrophil: 1.3 nTPM
  • eosinophil: 0.5 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 39 nTPM
  • choroid plexus: 15 nTPM
  • thalamus: 12 nTPM
  • cerebellum: 11 nTPM
  • medulla oblongata: 11 nTPM
  • pons: 9.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0.28
gnomAD missense Z
0.34
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM88 as an antibody target. Whether an autoantibody or antibody against TMEM88 could matter depends on whether native TMEM88 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM88 is annotated at the cell surface, where native TMEM88 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM88 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM88. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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