Seroatlas · Human Serome Atlas

TMEM87B

Transmembrane protein 87B

Also known as: FLJ14681, TM87B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96K49
Gene
TMEM87B
Ensembl
ENSG00000153214
Chromosome
2
Canonical length
555 aa
Protein class
Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene encodes a protein that may interact with human papillomavirus type 18 E6 oncogene. The protein is also likely to be involved in endosome-to-trans-Golgi network retrograde transport. The gene is expressed in adult and fetal tissues, including brain and heart. This gene is a component of the 2q13 deletion syndrome. Mutations in this gene may be associated with congenital heart defects. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

555 residues, UniProt reviewed canonical sequence.

>Q96K49|TMEM87B
     1  MVAACRSVAG LLPRRRRCFP ARAPLLRVAL CLLCWTPAAV RAVPELGLWL ETVNDKSGPL
    61  IFRKTMFNST DIKLSVKSFH CSGPVKFTIV WHLKYHTCHN EHSNLEELFQ KHKLSVDEDF
   121  CHYLKNDNCW TTKNENLDCN SDSQVFPSLN NKELINIRNV SNQERSMDVV ARTQKDGFHI
   181  FIVSIKTENT DASWNLNVSL SMIGPHGYIS ASDWPLMIFY MVMCIVYILY GILWLTWSAC
   241  YWKDILRIQF WIAAVIFLGM LEKAVFYSEY QNISNTGLST QGLLIFAELI SAIKRTLARL
   301  LVIIVSLGYG IVKPRLGTVM HRVIGLGLLY LIFAAVEGVM RVIGGSNHLA VVLDDIILAV
   361  IDSIFVWFIF ISLAQTMKTL RLRKNTVKFS LYRHFKNTLI FAVLASIVFM GWTTKTFRIA
   421  KCQSDWMERW VDDAFWSFLF SLILIVIMFL WRPSANNQRY AFMPLIDDSD DEIEEFMVTS
   481  ENLTEGIKLR ASKSVSNGTA KPATSENFDE DLKWVEENIP SSFTDVALPV LVDSDEEIMT
   541  RSEMAEKMFS SEKIM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM87B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 29 nTPM
  • small intestine: 28 nTPM
  • duodenum: 26 nTPM
  • colon: 26 nTPM
  • rectum: 26 nTPM
  • stomach: 21 nTPM

Single-cell type

  • prostatic glandular cells: 188 nCPM
  • breast lactating cells: 172 nCPM
  • mucous neck cells: 117 nCPM
  • goblet cells: 114 nCPM
  • adrenal cortex cells: 111 nCPM
  • gonadotrophs: 109 nCPM

Immune cell

  • non-classical monocyte: 6.3 nTPM
  • T-reg: 6.3 nTPM
  • memory CD4 T-cell: 5.8 nTPM
  • MAIT T-cell: 5.6 nTPM
  • memory B-cell: 5.6 nTPM
  • basophil: 5.4 nTPM

Brain region

  • midbrain: 16 nTPM
  • thalamus: 12 nTPM
  • pons: 12 nTPM
  • medulla oblongata: 10 nTPM
  • hypothalamus: 10 nTPM
  • spinal cord: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0
gnomAD missense Z
0.68
DepMap mean gene effect
-0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM87B as an antibody target. Whether an autoantibody or antibody against TMEM87B could matter depends on whether native TMEM87B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM87B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM87B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM87B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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