Seroatlas · Human Serome Atlas

TMEM87A

Transmembrane protein 87A

Also known as: DKFZP564G2022, TM87A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NBN3
Gene
TMEM87A
Ensembl
ENSG00000103978
Chromosome
15
Canonical length
555 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Involved in cellular response to mechanical stimulus and detection of mechanical stimulus involved in sensory perception of touch. Acts upstream of or within retrograde transport, endosome to Golgi. Located in Golgi cisterna membrane; plasma membrane; and ruffle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

555 residues, UniProt reviewed canonical sequence.

>Q8NBN3|TMEM87A
     1  MAAAAWLQVL PVILLLLGAH PSPLSFFSAG PATVAAADRS KWHIPIPSGK NYFSFGKILF
    61  RNTTIFLKFD GEPCDLSLNI TWYLKSADCY NEIYNFKAEE VELYLEKLKE KRGLSGKYQT
   121  SSKLFQNCSE LFKTQTFSGD FMHRLPLLGE KQEAKENGTN LTFIGDKTAM HEPLQTWQDA
   181  PYIFIVHIGI SSSKESSKEN SLSNLFTMTV EVKGPYEYLT LEDYPLMIFF MVMCIVYVLF
   241  GVLWLAWSAC YWRDLLRIQF WIGAVIFLGM LEKAVFYAEF QNIRYKGESV QGALILAELL
   301  SAVKRSLART LVIIVSLGYG IVKPRLGVTL HKVVVAGALY LLFSGMEGVL RVTGAQTDLA
   361  SLAFIPLAFL DTALCWWIFI SLTQTMKLLK LRRNIVKLSL YRHFTNTLIL AVAASIVFII
   421  WTTMKFRIVT CQSDWRELWV DDAIWRLLFS MILFVIMVLW RPSANNQRFA FSPLSEEEEE
   481  DEQKEPMLKE SFEGMKMRST KQEPNGNSKV NKAQEDDLKW VEENVPSSVT DVALPALLDS
   541  DEERMITHFE RSKME

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM87A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
76 nTPM

Expression across tissuesHPA

Tissue

  • breast: 76 nTPM
  • prostate: 62 nTPM
  • salivary gland: 60 nTPM
  • thyroid gland: 57 nTPM
  • lung: 56 nTPM
  • bone marrow: 51 nTPM

Single-cell type

  • alveolar cells type 2: 462 nCPM
  • epididymal basal cells: 412 nCPM
  • prostatic glandular cells: 397 nCPM
  • transitional alveolar cells: 351 nCPM
  • endometrial luminal cells: 335 nCPM
  • alveolar cells type 1: 330 nCPM

Immune cell

  • basophil: 36 nTPM
  • NK-cell: 22 nTPM
  • T-reg: 21 nTPM
  • MAIT T-cell: 19 nTPM
  • non-classical monocyte: 19 nTPM
  • naive CD4 T-cell: 18 nTPM

Brain region

  • white matter: 110 nTPM
  • medulla oblongata: 74 nTPM
  • basal ganglia: 70 nTPM
  • spinal cord: 61 nTPM
  • cerebellum: 61 nTPM
  • pons: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.08
gnomAD missense Z
1.39
DepMap mean gene effect
-0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM87A as an antibody target. Whether an autoantibody or antibody against TMEM87A could matter depends on whether native TMEM87A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM87A is annotated at the cell surface, where native TMEM87A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM87A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM87A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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