TMEM86B
Lysoplasmalogenase TMEM86B
Also known as: MGC30208, TM86B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N661
- Gene
- TMEM86B
- Ensembl
- ENSG00000180089
- Chromosome
- 19
- Canonical length
- 226 aa
- Protein class
- Enzymes, Predicted membrane proteins
- Subcellular location
- Midbody,Centrosome
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables D-lysine 5,6-aminomutase activity; alkenylglycerophosphocholine hydrolase activity; and identical protein binding activity. Involved in ether lipid metabolic process. Located in cytoplasm and membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
226 residues, UniProt reviewed canonical sequence.
>Q8N661|TMEM86B
1 MDAGKAGQTL KTHCSAQRPD VCRWLSPFIL SCCVYFCLWI PEDQLSWFAA LVKCLPVLCL
61 AGFLWVMSPS GGYTQLLQGA LVCSAVGDAC LIWPAAFVPG MAAFATAHLL YVWAFGFSPL
121 QPGLLLLIIL APGPYLSLVL QHLEPDMVLP VAAYGLILMA MLWRGLAQGG SAGWGALLFT
181 LSDGVLAWDT FAQPLPHAHL VIMTTYYAAQ LLITLSALRS PVPKTDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM86B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 8
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 47 nTPM
Expression across tissuesHPA
Tissue
- liver: 47 nTPM
- stomach: 15 nTPM
- gallbladder: 10 nTPM
- spleen: 10 nTPM
- testis: 10 nTPM
- basal ganglia: 10 nTPM
Single-cell type
- hepatocytes: 39 nCPM
- parietal cells: 39 nCPM
- cholangiocytes: 28 nCPM
- erythrocyte progenitors: 25 nCPM
- erythrocytes: 22 nCPM
- foveolar cells: 20 nCPM
Immune cell
- plasmacytoid DC: 0.6 nTPM
- naive CD8 T-cell: 0.5 nTPM
- gdT-cell: 0.4 nTPM
- classical monocyte: 0.3 nTPM
- neutrophil: 0.3 nTPM
- eosinophil: 0.2 nTPM
Brain region
- basal ganglia: 6.8 nTPM
- cerebral cortex: 6.7 nTPM
- cerebellum: 6.1 nTPM
- hippocampal formation: 5.7 nTPM
- amygdala: 5.6 nTPM
- medulla oblongata: 5.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.91
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.58
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- alkenylglycerophosphocholine hydrolase activity
- identical protein binding
- D-lysine 5,6-aminomutase activity
- ether hydrolase activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM86B as an antibody target. Whether an autoantibody or antibody against TMEM86B could matter depends on whether native TMEM86B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM86B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMEM86B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...