Seroatlas · Human Serome Atlas

TMEM86A

Lysoplasmalogenase TMEM86A

Also known as: FLJ90119, TM86A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N2M4
Gene: TMEM86A
Ensembl: ENSG00000151117
Chromosome: 11
Canonical length: 240 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Enables alkenylglycerophosphocholine hydrolase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>Q8N2M4|TMEM86A
     1  MVSPVTVVKS EGPKLVPFFK ATCVYFVLWL PSSSPSWVST LIKCLPIFCL WLFLLAHGLG
    61  FLLAHPSATR IFVGLVFSAV GDAFLIWQDQ GYFVHGLLMF AVTHMFYASA FGMQPLALRT
   121  GLVMAALSGL CYALLYPCLS GAFTYLVGVY VALIGFMGWR AMAGLRLAGA DWRWTELAAG
   181  SGALFFIISD LTIALNKFCF PVPYSRALIM STYYVAQMLV ALSAVESREP VEHYRLTKAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM86A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

skin: 17 nTPM
kidney: 8.8 nTPM
choroid plexus: 7.1 nTPM
ovary: 6.6 nTPM
retina: 5.3 nTPM
parathyroid gland: 5.1 nTPM

Single-cell type

hofbauer cells: 67 nCPM
kupffer cells: 28 nCPM
esophageal apical cells: 25 nCPM
late spermatids: 20 nCPM
late primary spermatocytes: 19 nCPM
retinal pigment epithelial cells: 17 nCPM

Immune cell

myeloid DC: 3.4 nTPM
plasmacytoid DC: 2 nTPM
classical monocyte: 1.9 nTPM
intermediate monocyte: 1.4 nTPM
naive CD8 T-cell: 0.9 nTPM
total PBMC: 0.8 nTPM

Brain region

white matter: 13 nTPM
thalamus: 12 nTPM
choroid plexus: 11 nTPM
medulla oblongata: 9.8 nTPM
midbrain: 9.1 nTPM
spinal cord: 9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0.02
gnomAD missense Z: 0.88
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

lipid metabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM86A as an antibody target. Whether an autoantibody or antibody against TMEM86A could matter depends on whether native TMEM86A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM86A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM86A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...