Seroatlas · Human Serome Atlas

TMEM82

Transmembrane protein 82

Also known as: TMM82_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0PJX8
Gene: TMEM82
Ensembl: ENSG00000162460
Chromosome: 1
Canonical length: 343 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

343 residues, UniProt reviewed canonical sequence.

>A0PJX8|TMEM82
     1  MFSLPSLPSW LPGLPSLEWG SSLLDSLLQG LIGALGVLVL NSLLKVYFFV GCANDPQRRP
    61  EKERLRAQWA SLETVHLAGL ALFLTVVGSR VAALVVLEFS LRAVSTLLSL GKGSQGAAER
   121  LQLYLLCQYS LGCGLTCGLS FLQEGAPHRT LNLLLSLGLA TLLGLGARRL HRHVCRLYEL
   181  HSSQRYCGVC LGLLAHAHGL PQLLGRALAI AFAVGDLAAV ALINQDFLTT SEAMRFWTPL
   241  TICYTLLVIY MQEEQRQHPG LQSQVQTVLV RMGGLFVLLL TVGRWLDLLG ILVSLLGELW
   301  CLVGVRTLLD LCQIQDFPSQ RPPVSTPSQP LPSAPQSQSS APS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM82 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

liver: 55 nTPM
duodenum: 23 nTPM
small intestine: 18 nTPM
kidney: 12 nTPM
colon: 6.6 nTPM
rectum: 1.1 nTPM

Single-cell type

enterocytes: 176 nCPM
hepatocytes: 62 nCPM
colonocytes: 51 nCPM
enteric transient amplifying cells: 22 nCPM
proximal tubule cells: 17 nCPM
goblet cells: 9.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.4 nTPM
amygdala: 0.1 nTPM
cerebellum: 0.1 nTPM
hippocampal formation: 0.1 nTPM
pons: 0.1 nTPM
basal ganglia: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: -0.04
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein 82
Transmembrane protein 82

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM82 as an antibody target. Whether an autoantibody or antibody against TMEM82 could matter depends on whether native TMEM82 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM82 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM82 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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