Seroatlas · Human Serome Atlas

TMEM81

Transmembrane protein 81

Also known as: HC3107, KVLA2788, MGC75217, TMM81_HUMAN, UNQ2788

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P7N7
Gene: TMEM81
Ensembl: ENSG00000174529
Chromosome: 1
Canonical length: 255 aa
Protein class: Predicted membrane proteins
Subcellular location: Intermediate filaments

OverviewNCBI Gene

Enables protein-macromolecule adaptor activity. Involved in sperm-egg recognition. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>Q6P7N7|TMEM81
     1  MKVLATSFVL GSLGLAFYLP LVVTTPKTLA IPEKLQEAVG KVIINATTCT VTCGLGYKEE
    61  TVCEVGPDGV RRKCQTRRLE CLTNWICGML HFTILIGKEF ELSCLSSDIL EFGQEAFRFT
   121  WRLARGVIST DDEVFKPFQA NSHFVKFKYA QEYDSGTYRC DVQLVKNLRL VKRLYFGLRV
   181  LPPNLVNLNF HQSLTEDQKL IDEGLEVNLD SYSKPHHPKW KKKVASALGI GIAIGVVGGV
   241  LVRIVLCALR GGLQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM81 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 16 nTPM
cerebral cortex: 7.5 nTPM
skeletal muscle: 6.3 nTPM
liver: 5.9 nTPM
basal ganglia: 5.6 nTPM
testis: 5.6 nTPM

Single-cell type

late primary spermatocytes: 15 nCPM
early spermatids: 12 nCPM
paneth cells: 7.7 nCPM
late spermatids: 3.3 nCPM
suprabasal keratinocytes: 2.8 nCPM
cholangiocytes: 2 nCPM

Immune cell

gdT-cell: 1.8 nTPM
basophil: 1.7 nTPM
naive CD8 T-cell: 1.4 nTPM
T-reg: 1.1 nTPM
neutrophil: 1 nTPM
memory CD4 T-cell: 0.8 nTPM

Brain region

cerebellum: 10 nTPM
cerebral cortex: 6.8 nTPM
white matter: 6.1 nTPM
thalamus: 5.9 nTPM
basal ganglia: 5.2 nTPM
hippocampal formation: 5.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: 0.25
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM81 as an antibody target. Whether an autoantibody or antibody against TMEM81 could matter depends on whether native TMEM81 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM81 is annotated at the cell surface, where native TMEM81 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM81 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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