Seroatlas · Human Serome Atlas

TMEM80

Transmembrane protein 80

Also known as: FLJ38216, TMM80_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96HE8
Gene: TMEM80
Ensembl: ENSG00000177042
Chromosome: 11
Canonical length: 143 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to be involved in non-motile cilium assembly. Predicted to be located in cilium and membrane. Predicted to be active in ciliary transition zone. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

143 residues, UniProt reviewed canonical sequence.

>Q96HE8|TMEM80
     1  MAAPRRGRGS STVLSSVPLQ MLFYLSGTYY ALYFLATLLM ITYKSQVFSY PHRYLVLDLA
    61  LLFLMGILEA VRLYLGTRGN LTEAERPLAA SLALTAGTAL LSAHFLLWQA LVLWADWALS
   121  ATLLALHGLE AVLQVVAIAA FTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM80 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 48 nTPM
esophagus: 41 nTPM
kidney: 39 nTPM
spleen: 35 nTPM
pituitary gland: 34 nTPM
cervix: 32 nTPM

Single-cell type

early primary spermatocytes: 67 nCPM
differentiating spermatogonia: 36 nCPM
esophageal apical cells: 31 nCPM
oocytes: 23 nCPM
undifferentiated spermatogonia: 15 nCPM
late primary spermatocytes: 13 nCPM

Immune cell

eosinophil: 38 nTPM
non-classical monocyte: 35 nTPM
naive B-cell: 32 nTPM
memory B-cell: 29 nTPM
classical monocyte: 29 nTPM
intermediate monocyte: 28 nTPM

Brain region

medulla oblongata: 34 nTPM
white matter: 30 nTPM
cerebellum: 29 nTPM
hippocampal formation: 29 nTPM
spinal cord: 29 nTPM
thalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.96
gnomAD pLI: 0
gnomAD missense Z: 0.44
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

non-motile cilium assembly

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM80 as an antibody target. Whether an autoantibody or antibody against TMEM80 could matter depends on whether native TMEM80 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM80 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM80 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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