Seroatlas · Human Serome Atlas

TMEM79

Transmembrane protein 79

Also known as: FLJ16057, FLJ32254, MATT, MGC13102, TMM79_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BSE2
Gene
TMEM79
Ensembl
ENSG00000163472
Chromosome
1
Canonical length
394 aa
Protein class
Disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoli fibrillar center

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in several processes, including epithelial cell maturation; establishment of skin barrier; and positive regulation of epidermis development. Predicted to act upstream of or within cornification; cuticle development; and hair follicle morphogenesis. Predicted to be located in Golgi apparatus; lysosome; and membrane. Predicted to be active in lysosomal membrane and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

394 residues, UniProt reviewed canonical sequence.

>Q9BSE2|TMEM79
     1  MTEQETLALL EVKRSDSPEK SSPQALVPNG RQPEGEGGAE SPGAESLRVG SSAGSPTAIE
    61  GAEDGLDSTV SEAATLPWGT GPQPSAPFPD PPGWRDIEPE PPESEPLTKL EELPEDDANL
   121  LPEKAARAFV PIDLQCIERQ PQEDLIVRCE AGEGECRTFM PPRVTHPDPT ERKWAEAVVR
   181  PPGCSCGGCG SCGDREWLRA VASVGAALIL FPCLLYGAYA FLPFDVPRLP TMSSRLIYTL
   241  RCGVFATFPI VLGILVYGLS LLCFSALRPF GEPRREVEIH RRYVAQSVQL FILYFFNLAV
   301  LSTYLPQDTL KLLPLLTGLF AVSRLIYWLT FAVGRSFRGF GYGLTFLPLL SMLMWNLYYM
   361  FVVEPERMLT ATESRLDYPD HARSASDYRP RPWG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM79 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
5
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
137 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 137 nTPM
  • skin: 89 nTPM
  • vagina: 59 nTPM
  • cervix: 48 nTPM
  • prostate: 27 nTPM
  • salivary gland: 22 nTPM

Single-cell type

  • esophageal apical cells: 1,075 nCPM
  • esophageal suprabasal cells: 348 nCPM
  • suprabasal keratinocytes: 146 nCPM
  • esophageal basal cells: 85 nCPM
  • prostatic glandular cells: 31 nCPM
  • endometrial luminal cells: 29 nCPM

Immune cell

  • neutrophil: 3.7 nTPM
  • eosinophil: 3 nTPM
  • naive CD8 T-cell: 2.4 nTPM
  • naive B-cell: 2.2 nTPM
  • T-reg: 2.1 nTPM
  • classical monocyte: 2 nTPM

Brain region

  • white matter: 8.4 nTPM
  • basal ganglia: 6 nTPM
  • medulla oblongata: 5.9 nTPM
  • cerebellum: 5.8 nTPM
  • midbrain: 5.8 nTPM
  • thalamus: 5.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMEM79.

Disease | ImmuneIEDB

Conditions an epitope on TMEM79 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
-0.42
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM79 as an antibody target. Whether an autoantibody or antibody against TMEM79 could matter depends on whether native TMEM79 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM79 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM79 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM79. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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