Seroatlas · Human Serome Atlas

TMEM78

Transmembrane protein 78

Also known as: TMM78_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T7P6
Gene
TMEM78
Canonical length
136 aa

OverviewNCBI Gene

No narrative summary is available for TMEM78 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

136 residues, UniProt reviewed canonical sequence.

>Q5T7P6|TMEM78
     1  MWLDTRNLGI VISCWKGVCV PQTTTLEMFY NDNDRVEESS NSYQIRREFL LPACLPAFLS
    61  FSTSFSFFLS FLPLSLSLFL PFFPSFFLSL SLSPSFLPSF LRQGLALSPR LECDGAIMIH
   121  CSLNIPGSSD PPTSAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM78 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.58

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
0.08

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM78 as an antibody target. Whether an autoantibody or antibody against TMEM78 could matter depends on whether native TMEM78 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM78 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM78 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM78. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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