Seroatlas · Human Serome Atlas

TMEM72

Transmembrane protein 72

Also known as: bA285G1.3, C10orf127, KSP37, TMM72_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0PK05
Gene: TMEM72
Ensembl: ENSG00000187783
Chromosome: 10
Canonical length: 275 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a transmembrane protein which may be expressed specifically in the kidney. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>A0PK05|TMEM72
     1  MQLQVFWTGL EYTCRLLGIT TAAVLIGVGT ETFLQGQFKS LAFYLLFTGA AVSICEGAYF
    61  VAQLLAICFQ CQPGSLADRV REKAHWLGCF QKFLAYLLLS VACFLHPVLV WHVTIPGSML
   121  IITGLAYFLL SKRKKRKAAP EVLASPEQYT DPSSSAVSTT GSGDTEQTYT FHGALKEGPS
   181  SLFIHMKSIL KGTKKPSALQ PPNTLMELSL EPADSLAKKK QVHFEDNLVR IVPSLAEGLD
   241  DGDSEPEETT SDTTPIIPPP QAPLFLSSLT ATGLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM72 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 77 nTPM

Expression across tissuesHPA

Tissue

kidney: 77 nTPM
choroid plexus: 45 nTPM
pancreas: 8.6 nTPM
rectum: 7.3 nTPM
colon: 6.4 nTPM
testis: 2.8 nTPM

Single-cell type

distal convoluted tubule cells: 209 nCPM
choroid plexus epithelial cells: 140 nCPM
renal connecting tubule cells: 125 nCPM
loop of henle epithelial cells: 122 nCPM
retinal pigment epithelial cells: 85 nCPM
renal collecting duct intercalated cells: 78 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 113 nTPM
hippocampal formation: 8.6 nTPM
thalamus: 5.7 nTPM
medulla oblongata: 4.9 nTPM
hypothalamus: 4.2 nTPM
midbrain: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.78
gnomAD missense Z: 0.07
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein 72
Transmembrane protein family 72

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM72 as an antibody target. Whether an autoantibody or antibody against TMEM72 could matter depends on whether native TMEM72 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM72 is annotated at the cell surface, where native TMEM72 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM72 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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