TMEM71
Transmembrane protein 71
Also known as: FLJ33069, TMM71_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6P5X7
- Gene
- TMEM71
- Ensembl
- ENSG00000165071
- Chromosome
- 8
- Canonical length
- 295 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Mitochondria
OverviewNCBI Gene
Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
295 residues, UniProt reviewed canonical sequence.
>Q6P5X7|TMEM71
1 MYRISQLMST PVASSSRLER EYAGELSPTC IFPSFTCDSL DGYHSFECGS IDPLTGSHYT
61 CRRSPRLLTN GYYIWTEDSF LCDKDGNITL NPSQTSVMYK ENLVRIFRKK KRICHSFSSL
121 FNLSTSKSWL HGSIFGDINS SPSEDNWLKG TRRLDTDHCN GNADDLDCSS LTDDWESGKM
181 NAESVITSSS SHIISQPPGG NSHSLSLQSQ LTASERFQEN SSDHSETRLL QEVFFQAILL
241 AVCLIISACA RWFMGEILAS VFTCSLMITV AYVKSLFLSL ASYFKTTACA RFVKILocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM71 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 2
- Mean surface accessibility (rSASA)
- 0.6
- Highest tissue expression
- 35 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 35 nTPM
- bone marrow: 32 nTPM
- thymus: 18 nTPM
- spleen: 16 nTPM
- appendix: 12 nTPM
- lymph node: 12 nTPM
Single-cell type
- neutrophils: 1,034 nCPM
- cardiomyocytes: 326 nCPM
- neutrophil progenitors: 281 nCPM
- nk-cells: 150 nCPM
- monocytes: 125 nCPM
- t-cells: 110 nCPM
Immune cell
- neutrophil: 271 nTPM
- eosinophil: 102 nTPM
- basophil: 62 nTPM
- MAIT T-cell: 58 nTPM
- classical monocyte: 56 nTPM
- total PBMC: 39 nTPM
Brain region
- cerebral cortex: 21 nTPM
- thalamus: 4.6 nTPM
- choroid plexus: 3.9 nTPM
- pons: 3.8 nTPM
- hypothalamus: 3.2 nTPM
- medulla oblongata: 2.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.45
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.37
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
- TMEM71 protein family
- TMEM71 protein family
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM71 as an antibody target. Whether an autoantibody or antibody against TMEM71 could matter depends on whether native TMEM71 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM71 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMEM71 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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