TMEM69
Transmembrane protein 69
Also known as: C1orf154, FLJ21029, TMM69_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5SWH9
- Gene
- TMEM69
- Ensembl
- ENSG00000159596
- Chromosome
- 1
- Canonical length
- 247 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
247 residues, UniProt reviewed canonical sequence.
>Q5SWH9|TMEM69
1 MLRFIQKFSQ ASSKILKYSF PVGLRTSRTD ILSLKMSLQQ NFSPCPRPWL SSSFPAYMSK
61 TQCYHTSPCS FKKQQKQALL ARPSSTITYL TDSPKPALCV TLAGLIPFVA PPLVMLMTKT
121 YIPILAFTQM AYGASFLSFL GGIRWGFALP EGSPAKPDYL NLASSAAPLF FSWFAFLISE
181 RLSEAIVTVI MGMGVAFHLE LFLLPHYPNW FKALRIVVTL LATFSFIITL VVKSSFPEKG
241 HKRPGQVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM69 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 5
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 30 nTPM
Expression across tissuesHPA
Tissue
- parathyroid gland: 30 nTPM
- heart muscle: 30 nTPM
- tonsil: 26 nTPM
- esophagus: 26 nTPM
- lymph node: 25 nTPM
- epididymis: 25 nTPM
Single-cell type
- oocytes: 193 nCPM
- syncytiotrophoblasts: 72 nCPM
- cytotrophoblasts: 72 nCPM
- migrating cytotrophoblasts: 72 nCPM
- esophageal basal cells: 52 nCPM
- esophageal apical cells: 51 nCPM
Immune cell
- non-classical monocyte: 35 nTPM
- intermediate monocyte: 26 nTPM
- classical monocyte: 25 nTPM
- myeloid DC: 22 nTPM
- memory B-cell: 17 nTPM
- naive B-cell: 16 nTPM
Brain region
- choroid plexus: 23 nTPM
- hippocampal formation: 21 nTPM
- midbrain: 18 nTPM
- white matter: 18 nTPM
- cerebellum: 17 nTPM
- hypothalamus: 17 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.63
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.2
- DepMap mean gene effect
- -0.16
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF3429
- Protein of unknown function (DUF3429)
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM69 as an antibody target. Whether an autoantibody or antibody against TMEM69 could matter depends on whether native TMEM69 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM69 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMEM69 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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