TMEM68
DGAT1/2-independent enzyme synthesizing storage lipids
Also known as: DIESL_HUMAN, FLJ32370
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96MH6
- Gene
- TMEM68
- Ensembl
- ENSG00000167904
- Chromosome
- 8
- Canonical length
- 324 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins, Transporters
- Subcellular location
- Vesicles
OverviewNCBI Gene
Enables phospholipid:diacylglycerol acyltransferase activity. Involved in triglyceride biosynthetic process. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
324 residues, UniProt reviewed canonical sequence.
>Q96MH6|TMEM68
1 MIDKNQTCGV GQDSVPYMIC LIHILEEWFG VEQLEDYLNF ANYLLWVFTP LILLILPYFT
61 IFLLYLTIIF LHIYKRKNVL KEAYSHNLWD GARKTVATLW DGHAAVWHGY EVHGMEKIPE
121 DGPALIIFYH GAIPIDFYYF MAKIFIHKGR TCRVVADHFV FKIPGFSLLL DVFCALHGPR
181 EKCVEILRSG HLLAISPGGV REALISDETY NIVWGHRRGF AQVAIDAKVP IIPMFTQNIR
241 EGFRSLGGTR LFRWLYEKFR YPFAPMYGGF PVKLRTYLGD PIPYDPQITA EELAEKTKNA
301 VQALIDKHQR IPGNIMSALL ERFHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM68 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 2
- Mean surface accessibility (rSASA)
- 0.29
- Highest tissue expression
- 20 nTPM
Expression across tissuesHPA
Tissue
- fallopian tube: 20 nTPM
- parathyroid gland: 16 nTPM
- kidney: 16 nTPM
- thyroid gland: 15 nTPM
- choroid plexus: 13 nTPM
- rectum: 13 nTPM
Single-cell type
- fallopian tube ciliated cells: 104 nCPM
- respiratory ciliated cells: 96 nCPM
- epididymal efferent duct ciliated cells: 58 nCPM
- endometrial ciliated cells: 57 nCPM
- gastric progenitor cells: 55 nCPM
- prostatic hillock cells: 50 nCPM
Immune cell
- basophil: 34 nTPM
- MAIT T-cell: 11 nTPM
- naive CD8 T-cell: 11 nTPM
- memory B-cell: 9.8 nTPM
- naive B-cell: 9.5 nTPM
- NK-cell: 9.3 nTPM
Brain region
- choroid plexus: 43 nTPM
- cerebellum: 42 nTPM
- white matter: 32 nTPM
- basal ganglia: 27 nTPM
- cerebral cortex: 26 nTPM
- hypothalamus: 25 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 1.25
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- 2-acylglycerol O-acyltransferase activity
- diacylglycerol O-acyltransferase activity
- phospholipid:diacylglycerol acyltransferase activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM68 as an antibody target. Whether an autoantibody or antibody against TMEM68 could matter depends on whether native TMEM68 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM68 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMEM68 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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