Seroatlas · Human Serome Atlas

TMEM64

Transmembrane protein 64

Also known as: DKFZp762C1112, TMM64_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6YI46
Gene
TMEM64
Ensembl
ENSG00000180694
Chromosome
8
Canonical length
380 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of osteoblast differentiation; and positive regulation of cell differentiation. Predicted to act upstream of or within regulation of ATP-dependent activity. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

380 residues, UniProt reviewed canonical sequence.

>Q6YI46|TMEM64
     1  MRSPGGILLQ ALPRLLQHAA LPGLAELPAR WALPRGAGGD GPADRLPRGG GASAAAAAAA
    61  ASGALLGAYL ERHGPPEASE LPEPGGALAG GPGSGGGGVV VGVAEVRNWR CCCLGSTCWC
   121  RSLVLVCVLA ALCFASLALV RRYLHHLLLW VESLDSLLGV LLFVVGFIVV SFPCGWGYIV
   181  LNVAAGYLYG FVLGMGLMMV GVLIGTFIAH VVCKRLLTAW VAARIQSSEK LSAVIRVVEG
   241  GSGLKVVALA RLTPIPFGLQ NAVFSITDLS LPNYLMASSV GLLPTQLLNS YLGTTLRTME
   301  DVIAEQSVSG YFVFCLQIII SIGLMFYVVH RAQVELNAAI VACEMELKSS LVKGNQPNTS
   361  GSSFYNKRTL TFSGGGINVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM64 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
137 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 137 nTPM
  • thyroid gland: 22 nTPM
  • choroid plexus: 20 nTPM
  • liver: 19 nTPM
  • salivary gland: 17 nTPM
  • seminal vesicle: 16 nTPM

Single-cell type

  • epididymal principal cells: 428 nCPM
  • choroid plexus epithelial cells: 230 nCPM
  • platelets: 135 nCPM
  • oligodendrocytes: 108 nCPM
  • pituicytes/fscs: 97 nCPM
  • alveolar cells type 2: 90 nCPM

Immune cell

  • NK-cell: 3.2 nTPM
  • memory B-cell: 3.1 nTPM
  • basophil: 2.7 nTPM
  • naive B-cell: 2 nTPM
  • MAIT T-cell: 1.9 nTPM
  • memory CD8 T-cell: 1.7 nTPM

Brain region

  • choroid plexus: 96 nTPM
  • white matter: 34 nTPM
  • medulla oblongata: 25 nTPM
  • basal ganglia: 24 nTPM
  • cerebral cortex: 22 nTPM
  • spinal cord: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0.49
gnomAD missense Z
0.62
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM64 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM64 as an antibody target. Whether an autoantibody or antibody against TMEM64 could matter depends on whether native TMEM64 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM64 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM64 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM64. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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