Seroatlas · Human Serome Atlas

TMEM63B

Mechanosensitive cation channel TMEM63B

Also known as: C6orf110, dJ421H19.2, DKFZp434P0531, TM63B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T3F8
Gene
TMEM63B
Ensembl
ENSG00000137216
Chromosome
6
Canonical length
832 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Actin filaments

OverviewNCBI Gene

Enables mechanosensitive monoatomic cation channel activity. Predicted to be involved in sensory perception of sound and surfactant secretion. Located in actin cytoskeleton; cytoplasmic vesicle membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

832 residues, UniProt reviewed canonical sequence.

>Q5T3F8|TMEM63B
     1  MLPFLLATLG TTALNNSNPK DYCYSARIRS TVLQGLPFGG VPTVLALDFM CFLALLFLFS
    61  ILRKVAWDYG RLALVTDADR LRRQERDRVE QEYVASAMHG DSHDRYERLT SVSSSVDFDQ
   121  RDNGFCSWLT AIFRIKDDEI RDKCGGDAVH YLSFQRHIIG LLVVVGVLSV GIVLPVNFSG
   181  DLLENNAYSF GRTTIANLKS GNNLLWLHTS FAFLYLLLTV YSMRRHTSKM RYKEDDLVKR
   241  TLFINGISKY AESEKIKKHF EEAYPNCTVL EARPCYNVAR LMFLDAERKK AERGKLYFTN
   301  LQSKENVPTM INPKPCGHLC CCVVRGCEQV EAIEYYTKLE QKLKEDYKRE KEKVNEKPLG
   361  MAFVTFHNET ITAIILKDFN VCKCQGCTCR GEPRPSSCSE SLHISNWTVS YAPDPQNIYW
   421  EHLSIRGFIW WLRCLVINVV LFILLFFLTT PAIIITTMDK FNVTKPVEYL NNPIITQFFP
   481  TLLLWCFSAL LPTIVYYSAF FEAHWTRSGE NRTTMHKCYT FLIFMVLLLP SLGLSSLDLF
   541  FRWLFDKKFL AEAAIRFECV FLPDNGAFFV NYVIASAFIG NAMDLLRIPG LLMYMIRLCL
   601  ARSAAERRNV KRHQAYEFQF GAAYAWMMCV FTVVMTYSIT CPIIVPFGLM YMLLKHLVDR
   661  YNLYYAYLPA KLDKKIHSGA VNQVVAAPIL CLFWLLFFST MRTGFLAPTS MFTFVVLVIT
   721  IVICLCHVCF GHFKYLSAHN YKIEHTETDT VDPRSNGRPP TAAAVPKSAK YIAQVLQDSE
   781  VDGDGDGAPG SSGDEPPSSS SQDEELLMPP DALTDTDFQS CEDSLIENEI HQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM63B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 46 nTPM
  • skin: 37 nTPM
  • liver: 37 nTPM
  • lung: 36 nTPM
  • cerebellum: 31 nTPM
  • esophagus: 31 nTPM

Single-cell type

  • alveolar cells type 1: 154 nCPM
  • late spermatids: 142 nCPM
  • alveolar cells type 2: 115 nCPM
  • foveolar cells: 109 nCPM
  • transitional alveolar cells: 104 nCPM
  • esophageal apical cells: 100 nCPM

Immune cell

  • classical monocyte: 0.4 nTPM
  • MAIT T-cell: 0.4 nTPM
  • T-reg: 0.4 nTPM
  • neutrophil: 0.3 nTPM
  • basophil: 0.2 nTPM
  • eosinophil: 0.2 nTPM

Brain region

  • hippocampal formation: 52 nTPM
  • cerebral cortex: 50 nTPM
  • hypothalamus: 43 nTPM
  • pons: 42 nTPM
  • thalamus: 41 nTPM
  • medulla oblongata: 40 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMEM63B.

Disease | AllUniProt

Conditions TMEM63B is implicated in, by any mechanism.

  • Developmental and epileptic encephalopathy 118 (DEE118) MIM:621250

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 149 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.17
gnomAD pLI
1
gnomAD missense Z
4.22
DepMap mean gene effect
-0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM63B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM63B as an antibody target. Whether an autoantibody or antibody against TMEM63B could matter depends on whether native TMEM63B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM63B is annotated at the cell surface, where native TMEM63B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM63B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM63B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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